Downregulation of TCF1 in HIV Infection Impairs T-cell Proliferative Capacity by Disrupting Mitochondrial Function

BACKGROUND: Despite the benefits of antiretroviral therapy (ART) for people with HIV, T-cell dysfunction cannot be fully restored. Metabolic dysregulation is associated with dysfunction of HIV-1-specific T-cells. Exploration of the factors regulating metabolic fitness can help reverse T-cell dysfunc...

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Detalles Bibliográficos
Autores principales: Cai, Hong-Jiao, Shi, Jue, Yin, Lin-Bo, Zheng, Jie-Fu, Fu, Ya-Jing, Jiang, Yong-Jun, Shang, Hong, Zhang, Zi-Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298517/
https://www.ncbi.nlm.nih.gov/pubmed/35875558
http://dx.doi.org/10.3389/fmicb.2022.880873

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