Shenmai-Yin decreased the clearance of nifedipine in rats: The involvement of time-dependent inhibition of nifedipine oxidation

The traditional Chinese herbal formula Shenmai-Yin (SY) and nifedipine have both been used to treat patients with cardiovascular disorders. Nifedipine is primarily oxidized by cytochrome P450 (CYP) 3A. The oxidation and pharmacokinetics of nifedipine were studied in rats in vitro and in vivo to illu...

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Detalles Bibliográficos
Autores principales: Wang, Hong-Jaan, Lu, Chung-Kuang, Chen, Wei-Ching, Chen, An-Chi, Ueng, Yune-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Food and Drug Administration 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298630/
https://www.ncbi.nlm.nih.gov/pubmed/30648582
http://dx.doi.org/10.1016/j.jfda.2018.10.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298630/
https://www.ncbi.nlm.nih.gov/pubmed/30648582
http://dx.doi.org/10.1016/j.jfda.2018.10.005

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