Cargando…

Synaptopathy in Guinea Pigs Induced by Noise Mimicking Human Experience and Associated Changes in Auditory Signal Processing

Noise induced synaptopathy (NIS) has been researched extensively since a large amount of synaptic loss without permanent threshold shift (PTS) was found in CBA mice after a brief noise exposure. However, efforts to translate these results to humans have met with little success—and might not be possi...

Descripción completa

Detalles Bibliográficos
Autores principales: Xia, Li, Ripley, Sara, Jiang, Zhenhua, Yin, Xue, Yu, Zhiping, Aiken, Steve J., Wang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298651/
https://www.ncbi.nlm.nih.gov/pubmed/35873820
http://dx.doi.org/10.3389/fnins.2022.935371
_version_ 1784750757542625280
author Xia, Li
Ripley, Sara
Jiang, Zhenhua
Yin, Xue
Yu, Zhiping
Aiken, Steve J.
Wang, Jian
author_facet Xia, Li
Ripley, Sara
Jiang, Zhenhua
Yin, Xue
Yu, Zhiping
Aiken, Steve J.
Wang, Jian
author_sort Xia, Li
collection PubMed
description Noise induced synaptopathy (NIS) has been researched extensively since a large amount of synaptic loss without permanent threshold shift (PTS) was found in CBA mice after a brief noise exposure. However, efforts to translate these results to humans have met with little success—and might not be possible since noise exposure used in laboratory animals is generally different from what is experienced by human subjects in real life. An additional problem is a lack of morphological data and reliable functional methods to quantify loss of afferent synapses in humans. Based on evidence for disproportionate synaptic loss for auditory nerve fibers (ANFs) with low spontaneous rates (LSR), coding-in-noise deficits (CIND) have been speculated to be the major difficulty associated with NIS without PTS. However, no robust evidence for this is available in humans or animals. This has led to a re-examination of the role of LSR ANFs in signal coding in high-level noise. The fluctuation profile model has been proposed to support a role for high-SR ANFs in the coding of high-level noise in combination with efferent control of cochlear gain. This study aimed to induce NIS by a low-level, intermittent noise exposure mimicking what is experienced in human life and examined the impact of the NIS on temporal processing under masking. It also evaluated the role of temporal fluctuation in evoking efferent feedback and the effects of NIS on this feedback.
format Online
Article
Text
id pubmed-9298651
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-92986512022-07-21 Synaptopathy in Guinea Pigs Induced by Noise Mimicking Human Experience and Associated Changes in Auditory Signal Processing Xia, Li Ripley, Sara Jiang, Zhenhua Yin, Xue Yu, Zhiping Aiken, Steve J. Wang, Jian Front Neurosci Neuroscience Noise induced synaptopathy (NIS) has been researched extensively since a large amount of synaptic loss without permanent threshold shift (PTS) was found in CBA mice after a brief noise exposure. However, efforts to translate these results to humans have met with little success—and might not be possible since noise exposure used in laboratory animals is generally different from what is experienced by human subjects in real life. An additional problem is a lack of morphological data and reliable functional methods to quantify loss of afferent synapses in humans. Based on evidence for disproportionate synaptic loss for auditory nerve fibers (ANFs) with low spontaneous rates (LSR), coding-in-noise deficits (CIND) have been speculated to be the major difficulty associated with NIS without PTS. However, no robust evidence for this is available in humans or animals. This has led to a re-examination of the role of LSR ANFs in signal coding in high-level noise. The fluctuation profile model has been proposed to support a role for high-SR ANFs in the coding of high-level noise in combination with efferent control of cochlear gain. This study aimed to induce NIS by a low-level, intermittent noise exposure mimicking what is experienced in human life and examined the impact of the NIS on temporal processing under masking. It also evaluated the role of temporal fluctuation in evoking efferent feedback and the effects of NIS on this feedback. Frontiers Media S.A. 2022-07-06 /pmc/articles/PMC9298651/ /pubmed/35873820 http://dx.doi.org/10.3389/fnins.2022.935371 Text en Copyright © 2022 Xia, Ripley, Jiang, Yin, Yu, Aiken and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Xia, Li
Ripley, Sara
Jiang, Zhenhua
Yin, Xue
Yu, Zhiping
Aiken, Steve J.
Wang, Jian
Synaptopathy in Guinea Pigs Induced by Noise Mimicking Human Experience and Associated Changes in Auditory Signal Processing
title Synaptopathy in Guinea Pigs Induced by Noise Mimicking Human Experience and Associated Changes in Auditory Signal Processing
title_full Synaptopathy in Guinea Pigs Induced by Noise Mimicking Human Experience and Associated Changes in Auditory Signal Processing
title_fullStr Synaptopathy in Guinea Pigs Induced by Noise Mimicking Human Experience and Associated Changes in Auditory Signal Processing
title_full_unstemmed Synaptopathy in Guinea Pigs Induced by Noise Mimicking Human Experience and Associated Changes in Auditory Signal Processing
title_short Synaptopathy in Guinea Pigs Induced by Noise Mimicking Human Experience and Associated Changes in Auditory Signal Processing
title_sort synaptopathy in guinea pigs induced by noise mimicking human experience and associated changes in auditory signal processing
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298651/
https://www.ncbi.nlm.nih.gov/pubmed/35873820
http://dx.doi.org/10.3389/fnins.2022.935371
work_keys_str_mv AT xiali synaptopathyinguineapigsinducedbynoisemimickinghumanexperienceandassociatedchangesinauditorysignalprocessing
AT ripleysara synaptopathyinguineapigsinducedbynoisemimickinghumanexperienceandassociatedchangesinauditorysignalprocessing
AT jiangzhenhua synaptopathyinguineapigsinducedbynoisemimickinghumanexperienceandassociatedchangesinauditorysignalprocessing
AT yinxue synaptopathyinguineapigsinducedbynoisemimickinghumanexperienceandassociatedchangesinauditorysignalprocessing
AT yuzhiping synaptopathyinguineapigsinducedbynoisemimickinghumanexperienceandassociatedchangesinauditorysignalprocessing
AT aikenstevej synaptopathyinguineapigsinducedbynoisemimickinghumanexperienceandassociatedchangesinauditorysignalprocessing
AT wangjian synaptopathyinguineapigsinducedbynoisemimickinghumanexperienceandassociatedchangesinauditorysignalprocessing