Sustainable Flow‐Synthesis of (Bulky) Nucleoside Drugs by a Novel and Highly Stable Nucleoside Phosphorylase Immobilized on Reusable Supports

The continuous synthesis of valuable nucleoside drugs was achieved in up to 99 % conversion by using a novel halotolerant purine nucleoside phosphorylase from Halomonas elongata (HePNP). HePNP showed an unprecedented tolerance to DMSO, usually required for substrate solubility, and could be immobili...

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Detalles Bibliográficos
Autores principales: Benítez‐Mateos, Ana I., Paradisi, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298701/
https://www.ncbi.nlm.nih.gov/pubmed/34726353
http://dx.doi.org/10.1002/cssc.202102030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298701/
https://www.ncbi.nlm.nih.gov/pubmed/34726353
http://dx.doi.org/10.1002/cssc.202102030

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