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Detection of Synergistic Interaction on an Additive Scale Between Two Drugs on Abnormal Elevation of Serum Alanine Aminotransferase Using Machine-Learning Algorithms

Drug-induced liver injury (DILI) is a common adverse drug reaction, with abnormal elevation of serum alanine aminotransferase (ALT). Several clinical studies have investigated whether a combination of two drugs alters the reporting frequency of DILI using traditional statistical methods such as mult...

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Detalles Bibliográficos
Autores principales:	Akimoto, Hayato, Nagashima, Takuya, Minagawa, Kimino, Hayakawa, Takashi, Takahashi, Yasuo, Asai, Satoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298751/ https://www.ncbi.nlm.nih.gov/pubmed/35873565 http://dx.doi.org/10.3389/fphar.2022.910205

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