GPR39 Deficiency Impairs Memory and Alters Oxylipins and Inflammatory Cytokines Without Affecting Cerebral Blood Flow in a High-Fat Diet Mouse Model of Cognitive Impairment

Vascular cognitive impairment (VCI) is the second most common cause of dementia. There is no treatment for VCI, in part due to a lack of understanding of the underlying mechanisms. The G-protein coupled receptor 39 (GPR39) is regulated by arachidonic acid (AA)-derived oxylipins that have been implic...

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Detalles Bibliográficos
Autores principales: Bah, Thierno M., Allen, Elyse M., Garcia-Jaramillo, Manuel, Perez, Ruby, Zarnegarnia, Yalda, Davis, Catherine M., Bloom, Madeline B., Magana, Armando A., Choi, Jaewoo, Bobe, Gerd, Pike, Martin M., Raber, Jacob, Maier, Claudia S., Alkayed, Nabil J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298837/
https://www.ncbi.nlm.nih.gov/pubmed/35875352
http://dx.doi.org/10.3389/fncel.2022.893030

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