Cargando…

In vitro metabolic profile of mexedrone, a mephedrone analog, studied by high‐ and low‐resolution mass spectrometry

Mexedrone is a synthetic cathinone structurally related to mephedrone, which belongs to the class of N‐alkyl cathinone derivatives, whose metabolic profile has not been fully clarified yet. This study considers the in vitro phase I metabolism of mexedrone, to pre‐select the most appropriate marker(s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Camuto, Cristian, Guglielmelli, Angelica, De‐Giorgio, Fabio, de la Torre, Xavier, Mazzarino, Monica, Marti, Matteo, Botrè, Francesco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298855/ https://www.ncbi.nlm.nih.gov/pubmed/34652887 http://dx.doi.org/10.1002/dta.3179

Ejemplares similares

Evaluation of Cytotoxic and Mutagenic Effects of the Synthetic Cathinones Mexedrone, α-PVP and α-PHP
por: Lenzi, Monia, et al.
Publicado: (2021)

Effects of the administration of miconazole by different routes on the biomarkers of the “steroidal module” of the Athlete Biological Passport
por: Mazzarino, Monica, et al.
Publicado: (2021)

Worsening of the Toxic Effects of (±)Cis-4,4′-DMAR Following Its Co-Administration with (±)Trans-4,4′-DMAR: Neuro-Behavioural, Physiological, Immunohistochemical and Metabolic Studies in Mice
por: Tirri, Micaela, et al.
Publicado: (2021)

In Vivo Bio-Activation of JWH-175 to JWH-018: Pharmacodynamic and Pharmacokinetic Studies in Mice
por: Tirri, Micaela, et al.
Publicado: (2022)

Mephedrone and Alcohol Interactions in Humans
por: Papaseit, Esther, et al.
Publicado: (2020)

UHPLC–HRMS Method for the Simultaneous Screening of 235 Drugs in Capillary Blood for Doping Control Purpose: Comparative Evaluation of Volumetric and Non-volumetric Dried Blood Spotting Devices
por: Mazzarino, Monica, et al.
Publicado: (2022)

Urinary excretion profile of prednisolone and prednisone after rectal administration: Significance in antidoping analysis
por: Iannella, Loredana, et al.
Publicado: (2022)

Acute Pharmacological Effects of Oral and Intranasal Mephedrone: An Observational Study in Humans
por: Papaseit, Esther, et al.
Publicado: (2021)

An observational study on the sub-acute effects of mephedrone on mood, cognition, sleep and physical problems in regular mephedrone users
por: Homman, Lina, et al.
Publicado: (2018)

Neurotoxicity Induced by Mephedrone: An up-to-date Review
por: Pantano, Flaminia, et al.
Publicado: (2017)

Psychoactive Substances Taken with Mephedrone and HCV Infection
por: Ordak, Michal, et al.
Publicado: (2021)

Urinary Elimination of Ecdysterone and Its Metabolites Following a Single-Dose Administration in Humans
por: Ambrosio, Gabriella, et al.
Publicado: (2021)

Fingertip Necrosis due to Intravascular Use of Mephedrone: A Case Report
por: Francés, Mónica, et al.
Publicado: (2018)

Chemsex drugs: More than ghb, mephedrone and methamphetamine?
por: Ramos, J. Curto, et al.
Publicado: (2021)

Alcohol Co-Administration Changes Mephedrone-Induced Alterations of Neuronal Activity
por: Grotell, Milo, et al.
Publicado: (2021)

Dose and Time-Dependent Selective Neurotoxicity Induced by Mephedrone in Mice
por: Martínez-Clemente, José, et al.
Publicado: (2014)

Mephedrone and Nicotine: Oxidative Stress and Behavioral Interactions in Animal Models
por: Budzynska, Barbara, et al.
Publicado: (2015)

Cocaine-Like Discriminative Stimulus Effects of Mephedrone and Naphyrone in Mice
por: Gannon, Brenda M., et al.
Publicado: (2016)

Effects of Hydroxylated Mephedrone Metabolites on Monoamine Transporter Activity in vitro
por: Niello, Marco, et al.
Publicado: (2021)

Central Effects of the Designer Drug Mephedrone in Mice—Basic Studies
por: Serefko, Anna, et al.
Publicado: (2022)

Drug Use on Mont Blanc: A Study Using Automated Urine Collection
por: Robach, Paul, et al.
Publicado: (2016)

Effect of -NBOMe Compounds on Sensorimotor, Motor, and Prepulse Inhibition Responses in Mice in Comparison With the 2C Analogs and Lysergic Acid Diethylamide: From Preclinical Evidence to Forensic Implication in Driving Under the Influence of Drugs
por: Tirri, Micaela, et al.
Publicado: (2022)

Severe Psychosis, Drug Dependence, and Hepatitis C Related to Slamming Mephedrone
por: Dolengevich-Segal, Helen, et al.
Publicado: (2016)

Clinical characteristics of mephedrone toxicity reported to the UK National Poisons Information Service
por: James, D, et al.
Publicado: (2010)

Phase I metabolites of mephedrone display biological activity as substrates at monoamine transporters
por: Mayer, F P, et al.
Publicado: (2016)

Mephedrone (4-Methylmethcathinone): Acute Behavioral Effects, Hyperthermic, and Pharmacokinetic Profile in Rats
por: Šíchová, Klára, et al.
Publicado: (2018)

The Effects of Exposure to Mephedrone During Adolescence on Brain Neurotransmission and Neurotoxicity in Adult Rats
por: Kamińska, Katarzyna, et al.
Publicado: (2018)

The psychoactive drug of abuse mephedrone differentially disrupts blood-brain barrier properties
por: Buzhdygan, Tetyana P., et al.
Publicado: (2021)

Development and application of a High-Resolution mass spectrometry method for the detection of fentanyl analogs in urine and serum
por: Zhang, Yu, et al.
Publicado: (2022)

Mephedrone in Adolescent Rats: Residual Memory Impairment and Acute but Not Lasting 5-HT Depletion
por: Motbey, Craig P., et al.
Publicado: (2012)

Evidence of 2 Populations of Mephedrone Abusers by Hair Testing. Application to 4 Forensic Expertises
por: Kintz, Pascal
Publicado: (2017)

Enantioseparation and Determination of Mephedrone and Its Metabolites by Capillary Electrophoresis Using Cyclodextrins as Chiral Selectors
por: Řezanka, Pavel, et al.
Publicado: (2020)

Insight into Glutamatergic Involvement in Rewarding Effects of Mephedrone in Rats: In Vivo and Ex Vivo Study
por: Wronikowska, Olga, et al.
Publicado: (2021)

Prescription Drug Misuse in “Clubbers” and Disco Goers in Ibiza
por: di Giannantonio, Massimo, et al.
Publicado: (2020)

Ultrahigh resolution mass spectrometry
por: Schmitt-Kopplin, Philippe, et al.
Publicado: (2007)

New non-randomised model to assess the prevalence of discriminating behaviour: a pilot study on mephedrone
por: Petróczi, Andrea, et al.
Publicado: (2011)

Effects of Mephedrone and Amphetamine Exposure during Adolescence on Spatial Memory in Adulthood: Behavioral and Neurochemical Analysis
por: Grochecki, Pawel, et al.
Publicado: (2021)

Pharmacokinetics of Mephedrone Enantiomers in Whole Blood after a Controlled Intranasal Administration to Healthy Human Volunteers
por: Czerwinska, Joanna, et al.
Publicado: (2020)

Alteration of Ethanol Reward by Prior Mephedrone Exposure: The Role of Age and Matrix Metalloproteinase-9 (MMP-9)
por: Grochecki, Pawel, et al.
Publicado: (2022)

Metabolism study and toxicological determination of mephtetramine in biological samples by liquid chromatography coupled with high‐resolution mass spectrometry
por: Odoardi, Sara, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4t2up59ke9upnu4fdjcpfm33ji