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Calcium supplementation during pregnancy and maternal and offspring bone health: a systematic review and meta‐analysis

Insufficient calcium intake during pregnancy may lead to maternal bone resorption and lower bone density of offspring. We evaluated the impact of supplementary calcium with or without vitamin D during pregnancy on maternal and offspring bone mineral density (BMD) and teeth firmness of the offspring....

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Autores principales: Tihtonen, Kati, Korhonen, Päivi, Isojärvi, Jaana, Ojala, Riitta, Ashorn, Ulla, Ashorn, Per, Tammela, Outi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298950/
https://www.ncbi.nlm.nih.gov/pubmed/34780069
http://dx.doi.org/10.1111/nyas.14705
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author Tihtonen, Kati
Korhonen, Päivi
Isojärvi, Jaana
Ojala, Riitta
Ashorn, Ulla
Ashorn, Per
Tammela, Outi
author_facet Tihtonen, Kati
Korhonen, Päivi
Isojärvi, Jaana
Ojala, Riitta
Ashorn, Ulla
Ashorn, Per
Tammela, Outi
author_sort Tihtonen, Kati
collection PubMed
description Insufficient calcium intake during pregnancy may lead to maternal bone resorption and lower bone density of offspring. We evaluated the impact of supplementary calcium with or without vitamin D during pregnancy on maternal and offspring bone mineral density (BMD) and teeth firmness of the offspring. Randomized controlled trials (RCTs) were searched systematically in 11 databases. Two researchers independently screened the titles and abstracts of 3555 records and the full texts of 31 records to examine eligibility. The search yielded seven RCTs (11 reports, n = 1566).  No advantage of calcium supplementation was found on maternal BMD after delivery or during breastfeeding, or on offspring BMD, even when dietary calcium intake was low. The results were neither modified by the dose of calcium nor concomitant vitamin D administration. A suspicion of some long‐term harm of the intervention on maternal BMD and growth of female offspring was raised based on the data. One study suggested some benefit of high‐dose calcium supplementation on offspring teeth firmness at 12 years old. A low number of the studies and abundant missing data reduced the quality of the findings. The impact of calcium supplementation on maternal and offspring bone health was deemed unknown because of inconclusive research results.
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spelling pubmed-92989502022-07-21 Calcium supplementation during pregnancy and maternal and offspring bone health: a systematic review and meta‐analysis Tihtonen, Kati Korhonen, Päivi Isojärvi, Jaana Ojala, Riitta Ashorn, Ulla Ashorn, Per Tammela, Outi Ann N Y Acad Sci Reviews Insufficient calcium intake during pregnancy may lead to maternal bone resorption and lower bone density of offspring. We evaluated the impact of supplementary calcium with or without vitamin D during pregnancy on maternal and offspring bone mineral density (BMD) and teeth firmness of the offspring. Randomized controlled trials (RCTs) were searched systematically in 11 databases. Two researchers independently screened the titles and abstracts of 3555 records and the full texts of 31 records to examine eligibility. The search yielded seven RCTs (11 reports, n = 1566).  No advantage of calcium supplementation was found on maternal BMD after delivery or during breastfeeding, or on offspring BMD, even when dietary calcium intake was low. The results were neither modified by the dose of calcium nor concomitant vitamin D administration. A suspicion of some long‐term harm of the intervention on maternal BMD and growth of female offspring was raised based on the data. One study suggested some benefit of high‐dose calcium supplementation on offspring teeth firmness at 12 years old. A low number of the studies and abundant missing data reduced the quality of the findings. The impact of calcium supplementation on maternal and offspring bone health was deemed unknown because of inconclusive research results. John Wiley and Sons Inc. 2021-11-15 2022-03 /pmc/articles/PMC9298950/ /pubmed/34780069 http://dx.doi.org/10.1111/nyas.14705 Text en © 2021 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals LLC on behalf of New York Academy of Sciences https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Tihtonen, Kati
Korhonen, Päivi
Isojärvi, Jaana
Ojala, Riitta
Ashorn, Ulla
Ashorn, Per
Tammela, Outi
Calcium supplementation during pregnancy and maternal and offspring bone health: a systematic review and meta‐analysis
title Calcium supplementation during pregnancy and maternal and offspring bone health: a systematic review and meta‐analysis
title_full Calcium supplementation during pregnancy and maternal and offspring bone health: a systematic review and meta‐analysis
title_fullStr Calcium supplementation during pregnancy and maternal and offspring bone health: a systematic review and meta‐analysis
title_full_unstemmed Calcium supplementation during pregnancy and maternal and offspring bone health: a systematic review and meta‐analysis
title_short Calcium supplementation during pregnancy and maternal and offspring bone health: a systematic review and meta‐analysis
title_sort calcium supplementation during pregnancy and maternal and offspring bone health: a systematic review and meta‐analysis
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298950/
https://www.ncbi.nlm.nih.gov/pubmed/34780069
http://dx.doi.org/10.1111/nyas.14705
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