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Structural Basis for Inhibition of ROS‐Producing Respiratory Complex I by NADH‐OH

NADH:ubiquinone oxidoreductase, respiratory complex I, plays a central role in cellular energy metabolism. As a major source of reactive oxygen species (ROS) it affects ageing and mitochondrial dysfunction. The novel inhibitor NADH‐OH specifically blocks NADH oxidation and ROS production by complex...

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Detalles Bibliográficos
Autores principales:	Vranas, Marta, Wohlwend, Daniel, Qiu, Danye, Gerhardt, Stefan, Trncik, Christian, Pervaiz, Mehrosh, Ritter, Kevin, Steimle, Stefan, Randazzo, Antonio, Einsle, Oliver, Günther, Stefan, Jessen, Henning J., Kotlyar, Alexander, Friedrich, Thorsten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299107/ https://www.ncbi.nlm.nih.gov/pubmed/34612584 http://dx.doi.org/10.1002/anie.202112165

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