Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex

De novo thymidylate synthesis is a crucial pathway for normal and cancer cells. Deoxythymidine monophosphate (dTMP) is synthesized by the combined action of three enzymes: serine hydroxymethyltransferase (SHMT1), dihydrofolate reductase (DHFR) and thymidylate synthase (TYMS), with the latter two bei...

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Detalles Bibliográficos
Autores principales: Spizzichino, Sharon, Boi, Dalila, Boumis, Giovanna, Lucchi, Roberta, Liberati, Francesca Romana, Capelli, Davide, Montanari, Roberta, Pochetti, Giorgio, Piacentini, Roberta, Parisi, Giacomo, Paone, Alessio, Rinaldo, Serena, Contestabile, Roberto, Tramonti, Angela, Paiardini, Alessandro, Giardina, Giorgio, Cutruzzolà, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299187/
https://www.ncbi.nlm.nih.gov/pubmed/34694685
http://dx.doi.org/10.1111/febs.16248

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