Inhibition of JMJD6 by 2‐Oxoglutarate Mimics

Studies on the inhibition of the human 2‐oxoglutarate dependent oxygenase JMJD6, which is a cancer target, by 2‐oxoglutarate mimics / competitors, including human drugs, drug candidates, and metabolites relevant to cancer are described. JMJD6 assays employed NMR to monitor inhibitor binding and use...

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Detalles Bibliográficos
Autores principales: Islam, Md. Sailful, Thinnes, Cyrille C., Holt‐Martyn, James P., Chowdhury, Rasheduzzaman, McDonough, Michael A., Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299220/
https://www.ncbi.nlm.nih.gov/pubmed/34581506
http://dx.doi.org/10.1002/cmdc.202100398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299220/
https://www.ncbi.nlm.nih.gov/pubmed/34581506
http://dx.doi.org/10.1002/cmdc.202100398

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