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High-frequency ultrasound detects biomechanical weakening in keratoconus with lower stiffness at higher grade
In vivo biomechanical characterization of the cornea remains a challenge. We have developed a high-frequency ultrasound elastography method, the ocular pulse elastography (OPE), to measure corneal axial displacement (CAD) induced by the ocular pulse. Here we compared CAD and a stiffness index derive...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299312/ https://www.ncbi.nlm.nih.gov/pubmed/35857808 http://dx.doi.org/10.1371/journal.pone.0271749 |
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author | Kwok, Sunny Pan, Xueliang Liu, William Hendershot, Andrew Liu, Jun |
author_facet | Kwok, Sunny Pan, Xueliang Liu, William Hendershot, Andrew Liu, Jun |
author_sort | Kwok, Sunny |
collection | PubMed |
description | In vivo biomechanical characterization of the cornea remains a challenge. We have developed a high-frequency ultrasound elastography method, the ocular pulse elastography (OPE), to measure corneal axial displacement (CAD) induced by the ocular pulse. Here we compared CAD and a stiffness index derived from CAD between keratoconus patients and normal controls. We also explored the trend of these parameters with keratoconus grade. Twenty normal subjects and twenty keratoconus patients were recruited in this study. Corneal topography, tomography, intraocular pressure (IOP) and ocular pulse amplitude (OPA) were obtained in each measured eye. The cornea’s heartbeat-induced cyclic axial displacements were measured by high-frequency (50 MHz) ultrasound. A corneal stiffness index (CSI) was derived from CAD normalized against OPA. CAD and CSI were compared between normal and keratoconus groups, and across keratoconus grades. Keratoconus corneas had significantly greater CAD and lower CSI than normal controls (p’s<0.01). Both parameters correlated strongly with grade, in which CAD increased significantly (p = 0.002) and CSI decreased significantly (p = 0.011) with grade. These results suggested a biomechanical weakening in keratoconus which worsens at higher disease severity. This study also demonstrated the ability of high-frequency ultrasound elastography to provide a safe, quick, and accurate evaluation of the cornea’s biomechanical condition in vivo. The OPE-measured biomechanical metrics, when integrated with existing diagnostic criteria, may aid the decision-making in the early and definitive diagnosis and staging of keratoconus. |
format | Online Article Text |
id | pubmed-9299312 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-92993122022-07-21 High-frequency ultrasound detects biomechanical weakening in keratoconus with lower stiffness at higher grade Kwok, Sunny Pan, Xueliang Liu, William Hendershot, Andrew Liu, Jun PLoS One Research Article In vivo biomechanical characterization of the cornea remains a challenge. We have developed a high-frequency ultrasound elastography method, the ocular pulse elastography (OPE), to measure corneal axial displacement (CAD) induced by the ocular pulse. Here we compared CAD and a stiffness index derived from CAD between keratoconus patients and normal controls. We also explored the trend of these parameters with keratoconus grade. Twenty normal subjects and twenty keratoconus patients were recruited in this study. Corneal topography, tomography, intraocular pressure (IOP) and ocular pulse amplitude (OPA) were obtained in each measured eye. The cornea’s heartbeat-induced cyclic axial displacements were measured by high-frequency (50 MHz) ultrasound. A corneal stiffness index (CSI) was derived from CAD normalized against OPA. CAD and CSI were compared between normal and keratoconus groups, and across keratoconus grades. Keratoconus corneas had significantly greater CAD and lower CSI than normal controls (p’s<0.01). Both parameters correlated strongly with grade, in which CAD increased significantly (p = 0.002) and CSI decreased significantly (p = 0.011) with grade. These results suggested a biomechanical weakening in keratoconus which worsens at higher disease severity. This study also demonstrated the ability of high-frequency ultrasound elastography to provide a safe, quick, and accurate evaluation of the cornea’s biomechanical condition in vivo. The OPE-measured biomechanical metrics, when integrated with existing diagnostic criteria, may aid the decision-making in the early and definitive diagnosis and staging of keratoconus. Public Library of Science 2022-07-20 /pmc/articles/PMC9299312/ /pubmed/35857808 http://dx.doi.org/10.1371/journal.pone.0271749 Text en © 2022 Kwok et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Kwok, Sunny Pan, Xueliang Liu, William Hendershot, Andrew Liu, Jun High-frequency ultrasound detects biomechanical weakening in keratoconus with lower stiffness at higher grade |
title | High-frequency ultrasound detects biomechanical weakening in keratoconus with lower stiffness at higher grade |
title_full | High-frequency ultrasound detects biomechanical weakening in keratoconus with lower stiffness at higher grade |
title_fullStr | High-frequency ultrasound detects biomechanical weakening in keratoconus with lower stiffness at higher grade |
title_full_unstemmed | High-frequency ultrasound detects biomechanical weakening in keratoconus with lower stiffness at higher grade |
title_short | High-frequency ultrasound detects biomechanical weakening in keratoconus with lower stiffness at higher grade |
title_sort | high-frequency ultrasound detects biomechanical weakening in keratoconus with lower stiffness at higher grade |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299312/ https://www.ncbi.nlm.nih.gov/pubmed/35857808 http://dx.doi.org/10.1371/journal.pone.0271749 |
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