Cargando…

A mRNA Vaccine Encoding for a RBD 60-mer Nanoparticle Elicits Neutralizing Antibodies and Protective Immunity Against the SARS-CoV-2 Delta Variant in Transgenic K18-hACE2 Mice

Two years into the COVID-19 pandemic there is still a need for vaccines to effectively control the spread of novel SARS-CoV-2 variants and associated cases of severe disease. Here we report a messenger RNA vaccine directly encoding for a nanoparticle displaying 60 receptor binding domains (RBDs) of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brandys, Pascal, Montagutelli, Xavier, Merenkova, Irena, Barut, Güliz T., Thiel, Volker, Schork, Nicholas J., Trüeb, Bettina, Conquet, Laurine, Deng, Aihua, Antanasijevic, Aleksandar, Lee, Hyun-Ku, Valière, Martine, Sindhu, Anoop, Singh, Gita, Herold, Jens
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299372/ https://www.ncbi.nlm.nih.gov/pubmed/35874687 http://dx.doi.org/10.3389/fimmu.2022.912898

Ejemplares similares

Exploring the disruption of SARS-CoV-2 RBD binding to hACE2
por: Carter, Camryn, et al.
Publicado: (2023)

Susceptibility to Zika virus in a Collaborative Cross mouse strain is induced by Irf3 deficiency in vitro but requires other variants in vivo
por: Bourdon, Marie, et al.
Publicado: (2023)

DNA aptamers inhibit SARS-CoV-2 spike-protein binding to hACE2 by an RBD- independent or dependent approach
por: Silwal, Achut Prasad, et al.
Publicado: (2022)

Computational design of medicinal compounds to inhibit RBD-hACE2 interaction in the Omicron variant: unveiling a vulnerable target site
por: Shahab, Muhammad, et al.
Publicado: (2023)

Blocking key mutated hotspot residues in the RBD of the omicron variant (B.1.1.529) with medicinal compounds to disrupt the RBD-hACE2 complex using molecular screening and simulation approaches
por: Khan, Abbas, et al.
Publicado: (2022)

hACE2 Fc-neutralization antibody cocktail provides synergistic protection against SARS-CoV-2 and its spike RBD variants
por: Liu, Junli, et al.
Publicado: (2021)

RBD-VLP Vaccines Adjuvanted with Alum or SWE Protect K18-hACE2 Mice against SARS-CoV-2 VOC Challenge
por: Wong, Ting Y., et al.
Publicado: (2022)

Evolutionary progression of collective mutations in Omicron sub-lineages towards efficient RBD-hACE2: Allosteric communications between and within viral and human proteins
por: Barozi, Victor, et al.
Publicado: (2022)

An efficient system to generate truncated human angiotensin converting enzyme 2 (hACE2) capable of binding RBD and spike protein of SARS-CoV2
por: Gao, Xiangzheng, et al.
Publicado: (2021)

A bioluminescent and homogeneous SARS-CoV-2 spike RBD and hACE2 interaction assay for antiviral screening and monitoring patient neutralizing antibody levels
por: Alves, Juliano, et al.
Publicado: (2021)

Investigation of the binding and dynamic features of A.30 variant revealed higher binding of RBD for hACE2 and escapes the neutralizing antibody: A molecular simulation approach
por: Shafiq, Athar, et al.
Publicado: (2022)

Passive immunization with equine RBD-specific Fab protects K18-hACE2-mice against Alpha or Beta variants of SARS-CoV-2
por: Barbier, Mariette, et al.
Publicado: (2022)

Intranasal VLP-RBD vaccine adjuvanted with BECC470 confers immunity against Delta SARS-CoV-2 challenge in K18-hACE2-mice
por: Lee, Katherine S, et al.
Publicado: (2023)

Targeting the RBD of Omicron Variant (B.1.1.529) with Medicinal Phytocompounds to Abrogate the Binding of Spike Glycoprotein with the hACE2 Using Computational Molecular Search and Simulation Approach
por: Hakami, Abdulrahim R.
Publicado: (2022)

MERS-CoV RBD-mRNA vaccine induces potent and broadly neutralizing antibodies with protection against MERS-CoV infection
por: Tai, Wanbo, et al.
Publicado: (2023)

Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression
por: Carossino, Mariano, et al.
Publicado: (2022)

Insights into the Binding of Receptor-Binding Domain (RBD) of SARS-CoV-2 Wild Type and B.1.620 Variant with hACE2 Using Molecular Docking and Simulation Approaches
por: Muhseen, Ziyad Tariq, et al.
Publicado: (2021)

E484K mutation in SARS-CoV-2 RBD enhances binding affinity with hACE2 but reduces interactions with neutralizing antibodies and nanobodies: Binding free energy calculation studies
por: Wang, Wei Bu, et al.
Publicado: (2021)

Comparative pathology of the nasal epithelium in K18-hACE2 Tg mice, hACE2 Tg mice, and hamsters infected with SARS-CoV-2
por: Yu, Pin, et al.
Publicado: (2022)

Comparative genomics, evolutionary epidemiology, and RBD-hACE2 receptor binding pattern in B.1.1.7 (Alpha) and B.1.617.2 (Delta) related to their pandemic response in UK and India
por: Chakraborty, Chiranjib, et al.
Publicado: (2022)

Hace mucho tiempo
por: Kennedy, Margaret, 1896-1967
Publicado: (1948)

Entropic contribution of ACE2 glycans to RBD binding
por: Mugnai, Mauro L., et al.
Publicado: (2023)

Wild Sambucus nigra L. from north-east edge of the species range: A valuable germplasm with inhibitory capacity against SARS-CoV2 S-protein RBD and hACE2 binding in vitro
por: Boroduske, Anete, et al.
Publicado: (2021)

Structural bioinformatics analysis of SARS-CoV-2 variants reveals higher hACE2 receptor binding affinity for Omicron B.1.1.529 spike RBD compared to wild type reference
por: Durmaz, Vedat, et al.
Publicado: (2022)

Computer aided prediction and identification of potential epitopes in the receptor binding domain (RBD) of spike (S) glycoprotein of MERS-CoV
por: ali, Mohammad Tuhin, et al.
Publicado: (2014)

Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas
por: Rodon, Jordi, et al.
Publicado: (2022)

Scanning the RBD-ACE2 molecular interactions in Omicron variant
por: Rath, Soumya Lipsa, et al.
Publicado: (2022)

Qué nos hace humanos
por: Ridley, Matt
Publicado: (2004)

El psicólogo ?que hace?
por: Harrsch, Catalina
Publicado: (1991)

Combining a Fusion Inhibitory Peptide Targeting the MERS-CoV S2 Protein HR1 Domain and a Neutralizing Antibody Specific for the S1 Protein Receptor-Binding Domain (RBD) Showed Potent Synergism against Pseudotyped MERS-CoV with or without Mutations in RBD
por: Wang, Cong, et al.
Publicado: (2019)

Thermophilic Filamentous Fungus C1-Cell-Cloned SARS-CoV-2-Spike-RBD-Subunit-Vaccine Adjuvanted with Aldydrogel(®)85 Protects K18-hACE2 Mice against Lethal Virus Challenge
por: Nechooshtan, Ram, et al.
Publicado: (2022)

Sodium oxybate—a new horizon for symptomatic treatment of RBD?
por: Stefani, Ambra, et al.
Publicado: (2023)

Pathogenicity of severe acute respiratory coronavirus deletion mutants in hACE-2 transgenic mice
por: DeDiego, Marta L., et al.
Publicado: (2008)

COVID-19 Treatments and Pathogenesis Including Anosmia in K18-hACE2 mice
por: Zheng, Jian, et al.
Publicado: (2020)

Attractive and repulsive residue fragments at the interface of SARS-CoV-2 and hACE2
por: Rodriguez, Jorge H.
Publicado: (2021)

Intranasal Exposure to Rift Valley Fever Virus Live-Attenuated Strains Leads to High Mortality Rate in Immunocompetent Mice
por: Lacote, Sandra, et al.
Publicado: (2022)

Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response
por: Manet, Caroline, et al.
Publicado: (2022)

HACE1 deficiency leads to structural and functional neurodevelopmental defects
por: Nagy, Vanja, et al.
Publicado: (2019)

Cómo se hace un proceso /
por: Carnelutti, Francesco, 1879-1965
Publicado: (2002)

Cómo se hace una película
por: Chabrol, Claude, 1930-2010
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_sfotbc8tq88blii209bqu3fbd8