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Sex Differences in Cutaneous Melanoma: Incidence, Clinicopathological Profile, Survival, and Costs
BACKGROUND: This study aims to provide a comprehensive overview of sex-related characteristics of cutaneous malignant melanoma (CMM), with special reference to its incidence, clinicopathological profile, overall survival, and treatment-related costs. METHODS: This retrospective cohort study included...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mary Ann Liebert, Inc., publishers
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299528/ https://www.ncbi.nlm.nih.gov/pubmed/35076310 http://dx.doi.org/10.1089/jwh.2021.0223 |
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author | Buja, Alessandra Rugge, Massimo Damiani, Giovanni Zorzi, Manuel De Toni, Chiara Vecchiato, Antonella Del Fiore, Paolo Spina, Romina Baldo, Vincenzo Brazzale, Alessandra Rosalba Rossi, Carlo Riccardo Mocellin, Simone |
author_facet | Buja, Alessandra Rugge, Massimo Damiani, Giovanni Zorzi, Manuel De Toni, Chiara Vecchiato, Antonella Del Fiore, Paolo Spina, Romina Baldo, Vincenzo Brazzale, Alessandra Rosalba Rossi, Carlo Riccardo Mocellin, Simone |
author_sort | Buja, Alessandra |
collection | PubMed |
description | BACKGROUND: This study aims to provide a comprehensive overview of sex-related characteristics of cutaneous malignant melanoma (CMM), with special reference to its incidence, clinicopathological profile, overall survival, and treatment-related costs. METHODS: This retrospective cohort study included all 1,279 CMM patients who were registered in 2015 in the Veneto Cancer Registry (a population-based registry including all 4,900,000 regional residents). The by-sex comparisons included tumor stage and site, histological subtype, and other clinical–pathological variables. A Cox regression analysis was used to test the association between sex and survival, adjusting for the main covariates. Treatment costs were calculated by linking patients with several administrative regional databases. RESULTS: Age-specific incidence rates were significantly higher for men among people >50 years old. For men, the trunk was the most common primary site (59.3%), whereas for women the lower limbs (32.1%) were the most common primary site, followed by the trunk (31.8%), which was lower than for men (p < 0.001). At presentation, the frequency of early stage CMM was higher among women, who also featured a significantly lower risk of death (p = 0.016), after adjusting for covariates. Men also incurred higher costs for melanoma treatment in the first year after their diagnosis. CONCLUSIONS: Among younger adults, CMM was more common in women, whereas among older adults, it was more common in men. Sex also influences patients' histopathological characteristics at diagnosis. Women had better overall survival after adjusting for demographic, pathological, and clinical profiles. The costs of treatment were also lower for women with CMM. |
format | Online Article Text |
id | pubmed-9299528 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Mary Ann Liebert, Inc., publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-92995282022-08-01 Sex Differences in Cutaneous Melanoma: Incidence, Clinicopathological Profile, Survival, and Costs Buja, Alessandra Rugge, Massimo Damiani, Giovanni Zorzi, Manuel De Toni, Chiara Vecchiato, Antonella Del Fiore, Paolo Spina, Romina Baldo, Vincenzo Brazzale, Alessandra Rosalba Rossi, Carlo Riccardo Mocellin, Simone J Womens Health (Larchmt) Original Articles BACKGROUND: This study aims to provide a comprehensive overview of sex-related characteristics of cutaneous malignant melanoma (CMM), with special reference to its incidence, clinicopathological profile, overall survival, and treatment-related costs. METHODS: This retrospective cohort study included all 1,279 CMM patients who were registered in 2015 in the Veneto Cancer Registry (a population-based registry including all 4,900,000 regional residents). The by-sex comparisons included tumor stage and site, histological subtype, and other clinical–pathological variables. A Cox regression analysis was used to test the association between sex and survival, adjusting for the main covariates. Treatment costs were calculated by linking patients with several administrative regional databases. RESULTS: Age-specific incidence rates were significantly higher for men among people >50 years old. For men, the trunk was the most common primary site (59.3%), whereas for women the lower limbs (32.1%) were the most common primary site, followed by the trunk (31.8%), which was lower than for men (p < 0.001). At presentation, the frequency of early stage CMM was higher among women, who also featured a significantly lower risk of death (p = 0.016), after adjusting for covariates. Men also incurred higher costs for melanoma treatment in the first year after their diagnosis. CONCLUSIONS: Among younger adults, CMM was more common in women, whereas among older adults, it was more common in men. Sex also influences patients' histopathological characteristics at diagnosis. Women had better overall survival after adjusting for demographic, pathological, and clinical profiles. The costs of treatment were also lower for women with CMM. Mary Ann Liebert, Inc., publishers 2022-07-01 2022-07-12 /pmc/articles/PMC9299528/ /pubmed/35076310 http://dx.doi.org/10.1089/jwh.2021.0223 Text en © Alessandra Buja et al. 2022; Published by Mary Ann Liebert, Inc. https://creativecommons.org/licenses/by/4.0/This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Buja, Alessandra Rugge, Massimo Damiani, Giovanni Zorzi, Manuel De Toni, Chiara Vecchiato, Antonella Del Fiore, Paolo Spina, Romina Baldo, Vincenzo Brazzale, Alessandra Rosalba Rossi, Carlo Riccardo Mocellin, Simone Sex Differences in Cutaneous Melanoma: Incidence, Clinicopathological Profile, Survival, and Costs |
title | Sex Differences in Cutaneous Melanoma: Incidence, Clinicopathological Profile, Survival, and Costs |
title_full | Sex Differences in Cutaneous Melanoma: Incidence, Clinicopathological Profile, Survival, and Costs |
title_fullStr | Sex Differences in Cutaneous Melanoma: Incidence, Clinicopathological Profile, Survival, and Costs |
title_full_unstemmed | Sex Differences in Cutaneous Melanoma: Incidence, Clinicopathological Profile, Survival, and Costs |
title_short | Sex Differences in Cutaneous Melanoma: Incidence, Clinicopathological Profile, Survival, and Costs |
title_sort | sex differences in cutaneous melanoma: incidence, clinicopathological profile, survival, and costs |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299528/ https://www.ncbi.nlm.nih.gov/pubmed/35076310 http://dx.doi.org/10.1089/jwh.2021.0223 |
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