Cargando…

Sex Differences in Cutaneous Melanoma: Incidence, Clinicopathological Profile, Survival, and Costs

BACKGROUND: This study aims to provide a comprehensive overview of sex-related characteristics of cutaneous malignant melanoma (CMM), with special reference to its incidence, clinicopathological profile, overall survival, and treatment-related costs. METHODS: This retrospective cohort study included...

Descripción completa

Detalles Bibliográficos
Autores principales: Buja, Alessandra, Rugge, Massimo, Damiani, Giovanni, Zorzi, Manuel, De Toni, Chiara, Vecchiato, Antonella, Del Fiore, Paolo, Spina, Romina, Baldo, Vincenzo, Brazzale, Alessandra Rosalba, Rossi, Carlo Riccardo, Mocellin, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299528/
https://www.ncbi.nlm.nih.gov/pubmed/35076310
http://dx.doi.org/10.1089/jwh.2021.0223
_version_ 1784750995340787712
author Buja, Alessandra
Rugge, Massimo
Damiani, Giovanni
Zorzi, Manuel
De Toni, Chiara
Vecchiato, Antonella
Del Fiore, Paolo
Spina, Romina
Baldo, Vincenzo
Brazzale, Alessandra Rosalba
Rossi, Carlo Riccardo
Mocellin, Simone
author_facet Buja, Alessandra
Rugge, Massimo
Damiani, Giovanni
Zorzi, Manuel
De Toni, Chiara
Vecchiato, Antonella
Del Fiore, Paolo
Spina, Romina
Baldo, Vincenzo
Brazzale, Alessandra Rosalba
Rossi, Carlo Riccardo
Mocellin, Simone
author_sort Buja, Alessandra
collection PubMed
description BACKGROUND: This study aims to provide a comprehensive overview of sex-related characteristics of cutaneous malignant melanoma (CMM), with special reference to its incidence, clinicopathological profile, overall survival, and treatment-related costs. METHODS: This retrospective cohort study included all 1,279 CMM patients who were registered in 2015 in the Veneto Cancer Registry (a population-based registry including all 4,900,000 regional residents). The by-sex comparisons included tumor stage and site, histological subtype, and other clinical–pathological variables. A Cox regression analysis was used to test the association between sex and survival, adjusting for the main covariates. Treatment costs were calculated by linking patients with several administrative regional databases. RESULTS: Age-specific incidence rates were significantly higher for men among people >50 years old. For men, the trunk was the most common primary site (59.3%), whereas for women the lower limbs (32.1%) were the most common primary site, followed by the trunk (31.8%), which was lower than for men (p < 0.001). At presentation, the frequency of early stage CMM was higher among women, who also featured a significantly lower risk of death (p = 0.016), after adjusting for covariates. Men also incurred higher costs for melanoma treatment in the first year after their diagnosis. CONCLUSIONS: Among younger adults, CMM was more common in women, whereas among older adults, it was more common in men. Sex also influences patients' histopathological characteristics at diagnosis. Women had better overall survival after adjusting for demographic, pathological, and clinical profiles. The costs of treatment were also lower for women with CMM.
format Online
Article
Text
id pubmed-9299528
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Mary Ann Liebert, Inc., publishers
record_format MEDLINE/PubMed
spelling pubmed-92995282022-08-01 Sex Differences in Cutaneous Melanoma: Incidence, Clinicopathological Profile, Survival, and Costs Buja, Alessandra Rugge, Massimo Damiani, Giovanni Zorzi, Manuel De Toni, Chiara Vecchiato, Antonella Del Fiore, Paolo Spina, Romina Baldo, Vincenzo Brazzale, Alessandra Rosalba Rossi, Carlo Riccardo Mocellin, Simone J Womens Health (Larchmt) Original Articles BACKGROUND: This study aims to provide a comprehensive overview of sex-related characteristics of cutaneous malignant melanoma (CMM), with special reference to its incidence, clinicopathological profile, overall survival, and treatment-related costs. METHODS: This retrospective cohort study included all 1,279 CMM patients who were registered in 2015 in the Veneto Cancer Registry (a population-based registry including all 4,900,000 regional residents). The by-sex comparisons included tumor stage and site, histological subtype, and other clinical–pathological variables. A Cox regression analysis was used to test the association between sex and survival, adjusting for the main covariates. Treatment costs were calculated by linking patients with several administrative regional databases. RESULTS: Age-specific incidence rates were significantly higher for men among people >50 years old. For men, the trunk was the most common primary site (59.3%), whereas for women the lower limbs (32.1%) were the most common primary site, followed by the trunk (31.8%), which was lower than for men (p < 0.001). At presentation, the frequency of early stage CMM was higher among women, who also featured a significantly lower risk of death (p = 0.016), after adjusting for covariates. Men also incurred higher costs for melanoma treatment in the first year after their diagnosis. CONCLUSIONS: Among younger adults, CMM was more common in women, whereas among older adults, it was more common in men. Sex also influences patients' histopathological characteristics at diagnosis. Women had better overall survival after adjusting for demographic, pathological, and clinical profiles. The costs of treatment were also lower for women with CMM. Mary Ann Liebert, Inc., publishers 2022-07-01 2022-07-12 /pmc/articles/PMC9299528/ /pubmed/35076310 http://dx.doi.org/10.1089/jwh.2021.0223 Text en © Alessandra Buja et al. 2022; Published by Mary Ann Liebert, Inc. https://creativecommons.org/licenses/by/4.0/This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Buja, Alessandra
Rugge, Massimo
Damiani, Giovanni
Zorzi, Manuel
De Toni, Chiara
Vecchiato, Antonella
Del Fiore, Paolo
Spina, Romina
Baldo, Vincenzo
Brazzale, Alessandra Rosalba
Rossi, Carlo Riccardo
Mocellin, Simone
Sex Differences in Cutaneous Melanoma: Incidence, Clinicopathological Profile, Survival, and Costs
title Sex Differences in Cutaneous Melanoma: Incidence, Clinicopathological Profile, Survival, and Costs
title_full Sex Differences in Cutaneous Melanoma: Incidence, Clinicopathological Profile, Survival, and Costs
title_fullStr Sex Differences in Cutaneous Melanoma: Incidence, Clinicopathological Profile, Survival, and Costs
title_full_unstemmed Sex Differences in Cutaneous Melanoma: Incidence, Clinicopathological Profile, Survival, and Costs
title_short Sex Differences in Cutaneous Melanoma: Incidence, Clinicopathological Profile, Survival, and Costs
title_sort sex differences in cutaneous melanoma: incidence, clinicopathological profile, survival, and costs
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299528/
https://www.ncbi.nlm.nih.gov/pubmed/35076310
http://dx.doi.org/10.1089/jwh.2021.0223
work_keys_str_mv AT bujaalessandra sexdifferencesincutaneousmelanomaincidenceclinicopathologicalprofilesurvivalandcosts
AT ruggemassimo sexdifferencesincutaneousmelanomaincidenceclinicopathologicalprofilesurvivalandcosts
AT damianigiovanni sexdifferencesincutaneousmelanomaincidenceclinicopathologicalprofilesurvivalandcosts
AT zorzimanuel sexdifferencesincutaneousmelanomaincidenceclinicopathologicalprofilesurvivalandcosts
AT detonichiara sexdifferencesincutaneousmelanomaincidenceclinicopathologicalprofilesurvivalandcosts
AT vecchiatoantonella sexdifferencesincutaneousmelanomaincidenceclinicopathologicalprofilesurvivalandcosts
AT delfiorepaolo sexdifferencesincutaneousmelanomaincidenceclinicopathologicalprofilesurvivalandcosts
AT spinaromina sexdifferencesincutaneousmelanomaincidenceclinicopathologicalprofilesurvivalandcosts
AT baldovincenzo sexdifferencesincutaneousmelanomaincidenceclinicopathologicalprofilesurvivalandcosts
AT brazzalealessandrarosalba sexdifferencesincutaneousmelanomaincidenceclinicopathologicalprofilesurvivalandcosts
AT rossicarloriccardo sexdifferencesincutaneousmelanomaincidenceclinicopathologicalprofilesurvivalandcosts
AT mocellinsimone sexdifferencesincutaneousmelanomaincidenceclinicopathologicalprofilesurvivalandcosts