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G6PD-mediated increase in de novo NADP(+) biosynthesis promotes antioxidant defense and tumor metastasis

Metastasizing cancer cells are able to withstand high levels of oxidative stress through mechanisms that are poorly understood. Here, we show that under various oxidative stress conditions, pancreatic cancer cells markedly expand NADPH and NADP(+) pools. This expansion is due to up-regulation of glu...

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Detalles Bibliográficos
Autores principales:	Zhang, Yang, Xu, Yi, Lu, Wenyun, Li, Jinyang, Yu, Sixiang, Brown, Eric J., Stanger, Ben Z., Rabinowitz, Joshua D., Yang, Xiaolu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299539/ https://www.ncbi.nlm.nih.gov/pubmed/35857842 http://dx.doi.org/10.1126/sciadv.abo0404

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