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Structural analyses of human ryanodine receptor type 2 channels reveal the mechanisms for sudden cardiac death and treatment

Ryanodine receptor type 2 (RyR2) mutations have been linked to an inherited form of exercise-induced sudden cardiac death called catecholaminergic polymorphic ventricular tachycardia (CPVT). CPVT results from stress-induced sarcoplasmic reticular Ca(2+) leak via the mutant RyR2 channels during diast...

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Detalles Bibliográficos
Autores principales:	Miotto, Marco C., Weninger, Gunnar, Dridi, Haikel, Yuan, Qi, Liu, Yang, Wronska, Anetta, Melville, Zephan, Sittenfeld, Leah, Reiken, Steven, Marks, Andrew R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299551/ https://www.ncbi.nlm.nih.gov/pubmed/35857850 http://dx.doi.org/10.1126/sciadv.abo1272

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