Electro-mechanical coupling of KCNQ channels is a target of epilepsy-associated mutations and retigabine

KCNQ2 and KCNQ3 form the M-channels that are important in regulating neuronal excitability. Inherited mutations that alter voltage-dependent gating of M-channels are associated with neonatal epilepsy. In the homolog KCNQ1 channel, two steps of voltage sensor activation lead to two functionally disti...

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Detalles Bibliográficos
Autores principales: Yang, Nien-Du, Kanyo, Richard, Zhao, Lu, Li, Jingru, Kang, Po Wei, Dou, Alex Kelly, White, Kelli McFarland, Shi, Jingyi, Nerbonne, Jeanne M., Kurata, Harley T., Cui, Jianmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299555/
https://www.ncbi.nlm.nih.gov/pubmed/35857840
http://dx.doi.org/10.1126/sciadv.abo3625

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