Population pharmacokinetics of clonazepam in saliva and plasma: Steps towards noninvasive pharmacokinetic studies in vulnerable populations

AIM: Traditional studies focusing on the relationship between pharmacokinetics (PK) and pharmacodynamics necessitate blood draws, which are too invasive for children or other vulnerable populations. A potential solution is to use noninvasive sampling matrices, such as saliva. The aim of this study w...

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Detalles Bibliográficos
Autores principales: Kruizinga, Matthijs D., Zuiker, Rob G. J. A., Bergmann, Kirsten R., Egas, Annelies C., Cohen, Adam F., Santen, Gijs W. E., van Esdonk, Michiel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299763/
https://www.ncbi.nlm.nih.gov/pubmed/34811788
http://dx.doi.org/10.1111/bcp.15152

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