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Mechanochemical Preparation of Protein : hydantoin Hybrids and Their Release Properties
Mechanochemistry is a versatile methodology that can be employed both for covalent bond formation in organic synthesis as well as a mediator to allow preparation novel colloidal dispersions for drug delivery. Herein, ball‐milling was employed for the solid‐state preparation of fluorescent hydrophobi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299789/ https://www.ncbi.nlm.nih.gov/pubmed/34817915 http://dx.doi.org/10.1002/cssc.202102097 |
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author | Yuan, Yusheng Wang, Lei Porcheddu, Andrea Colacino, Evelina Solin, Niclas |
author_facet | Yuan, Yusheng Wang, Lei Porcheddu, Andrea Colacino, Evelina Solin, Niclas |
author_sort | Yuan, Yusheng |
collection | PubMed |
description | Mechanochemistry is a versatile methodology that can be employed both for covalent bond formation in organic synthesis as well as a mediator to allow preparation novel colloidal dispersions for drug delivery. Herein, ball‐milling was employed for the solid‐state preparation of fluorescent hydrophobic hydantoins, followed by the unprecedented mechanochemically‐mediated complexation of hydrophobic hydantoins within hydrophilic protein β‐lactoglobulin (BLG) and BLG nanofibrils (BLGNFs). These hydantoin:protein materials were in turn incorporated into hydrogels. The effect of incorporation of hydantoins into proteins, as well as the effect of protein structure, on the release properties were then investigated. The conversion of BLG to BLGNFs led to a more sustained release demonstrating that heat treatment of BLG into BLGNFs could be employed to modify release properties. To the best of our knowledge, this is the first example where protein : hydantoin complexes were prepared by mechanochemical methodology and mechanochemistry was combined with self‐assembly in order to prepare protein nanomaterials for drug‐delivery applications. In addition, the use of the developed protein materials is not limited to delivery of drugs but can for example be employed as components of smart food (delivery of nutrients) or release systems of pesticides. |
format | Online Article Text |
id | pubmed-9299789 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92997892022-07-21 Mechanochemical Preparation of Protein : hydantoin Hybrids and Their Release Properties Yuan, Yusheng Wang, Lei Porcheddu, Andrea Colacino, Evelina Solin, Niclas ChemSusChem Full Papers Mechanochemistry is a versatile methodology that can be employed both for covalent bond formation in organic synthesis as well as a mediator to allow preparation novel colloidal dispersions for drug delivery. Herein, ball‐milling was employed for the solid‐state preparation of fluorescent hydrophobic hydantoins, followed by the unprecedented mechanochemically‐mediated complexation of hydrophobic hydantoins within hydrophilic protein β‐lactoglobulin (BLG) and BLG nanofibrils (BLGNFs). These hydantoin:protein materials were in turn incorporated into hydrogels. The effect of incorporation of hydantoins into proteins, as well as the effect of protein structure, on the release properties were then investigated. The conversion of BLG to BLGNFs led to a more sustained release demonstrating that heat treatment of BLG into BLGNFs could be employed to modify release properties. To the best of our knowledge, this is the first example where protein : hydantoin complexes were prepared by mechanochemical methodology and mechanochemistry was combined with self‐assembly in order to prepare protein nanomaterials for drug‐delivery applications. In addition, the use of the developed protein materials is not limited to delivery of drugs but can for example be employed as components of smart food (delivery of nutrients) or release systems of pesticides. John Wiley and Sons Inc. 2021-12-09 2022-01-21 /pmc/articles/PMC9299789/ /pubmed/34817915 http://dx.doi.org/10.1002/cssc.202102097 Text en © 2021 The Authors. ChemSusChem published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Full Papers Yuan, Yusheng Wang, Lei Porcheddu, Andrea Colacino, Evelina Solin, Niclas Mechanochemical Preparation of Protein : hydantoin Hybrids and Their Release Properties |
title | Mechanochemical Preparation of Protein : hydantoin Hybrids and Their Release Properties |
title_full | Mechanochemical Preparation of Protein : hydantoin Hybrids and Their Release Properties |
title_fullStr | Mechanochemical Preparation of Protein : hydantoin Hybrids and Their Release Properties |
title_full_unstemmed | Mechanochemical Preparation of Protein : hydantoin Hybrids and Their Release Properties |
title_short | Mechanochemical Preparation of Protein : hydantoin Hybrids and Their Release Properties |
title_sort | mechanochemical preparation of protein : hydantoin hybrids and their release properties |
topic | Full Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299789/ https://www.ncbi.nlm.nih.gov/pubmed/34817915 http://dx.doi.org/10.1002/cssc.202102097 |
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