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Point‐of‐care hepatitis C testing and treatment strategy for people attending harm reduction and addiction centres for hepatitis C elimination
According to WHO goals, the elimination of Hepatitis C Virus (HCV) by 2030 requires enhancing and simplifying HCV testing. Our aim was to create a model to assess and compare different strategies for HCV testing, linkage to care and treatment among people who access harm reduction centres (HRC) and...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299793/ https://www.ncbi.nlm.nih.gov/pubmed/34806812 http://dx.doi.org/10.1111/jvh.13634 |
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author | Forns, Xavier Colom, Joan García‐Retortillo, Montse Quer, Joan Carles Lens, Sabela Martró, Elisa Domínguez‐Hernández, Raquel Casado, Miguel Ángel Buti, María |
author_facet | Forns, Xavier Colom, Joan García‐Retortillo, Montse Quer, Joan Carles Lens, Sabela Martró, Elisa Domínguez‐Hernández, Raquel Casado, Miguel Ángel Buti, María |
author_sort | Forns, Xavier |
collection | PubMed |
description | According to WHO goals, the elimination of Hepatitis C Virus (HCV) by 2030 requires enhancing and simplifying HCV testing. Our aim was to create a model to assess and compare different strategies for HCV testing, linkage to care and treatment among people who access harm reduction centres (HRC) and Addiction Centres in Catalonia. A decision tree model was designed to evaluate two strategies: Hepatitis C Point‐of‐care (POC) “test and treat”, at the community versus standard‐of‐care (SOC), in which HCV testing was performed at community and therapy at the hospital. Both strategies were assessed separately in HRCs (6,878 users) and Addiction Centres (13,778 users). with a time horizon of 18 months. Healthcare outcomes were HCV testing, linkage to care, treatment outcomes and reinfection rate. HCV testing was performed in 3,178 (46%) of the HRC users. Compared with SOC, POC increased access to treatment by 57% (63% vs. 6%). SVR rates were 64% in POC vs. 23% in SOC. Reinfection rates were 21% with POC compared to 24% with SOC. With POC, losses to follow‐up were reduced by 41%. In the Addiction Centres, 12,566 users (91%) were screened using the two strategies. Compared to the SOC, POC increased access to treatment and linkage to care by 19% along with SVR at the same rate. Reinfection rates decreased by 6%. Thus, the implementation of a POC “test and treat” strategy at HRCs and Addiction Centres has shown to be an effective public health strategy to help eliminating HCV in accordance with WHO goal. |
format | Online Article Text |
id | pubmed-9299793 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92997932022-07-21 Point‐of‐care hepatitis C testing and treatment strategy for people attending harm reduction and addiction centres for hepatitis C elimination Forns, Xavier Colom, Joan García‐Retortillo, Montse Quer, Joan Carles Lens, Sabela Martró, Elisa Domínguez‐Hernández, Raquel Casado, Miguel Ángel Buti, María J Viral Hepat Short Communication According to WHO goals, the elimination of Hepatitis C Virus (HCV) by 2030 requires enhancing and simplifying HCV testing. Our aim was to create a model to assess and compare different strategies for HCV testing, linkage to care and treatment among people who access harm reduction centres (HRC) and Addiction Centres in Catalonia. A decision tree model was designed to evaluate two strategies: Hepatitis C Point‐of‐care (POC) “test and treat”, at the community versus standard‐of‐care (SOC), in which HCV testing was performed at community and therapy at the hospital. Both strategies were assessed separately in HRCs (6,878 users) and Addiction Centres (13,778 users). with a time horizon of 18 months. Healthcare outcomes were HCV testing, linkage to care, treatment outcomes and reinfection rate. HCV testing was performed in 3,178 (46%) of the HRC users. Compared with SOC, POC increased access to treatment by 57% (63% vs. 6%). SVR rates were 64% in POC vs. 23% in SOC. Reinfection rates were 21% with POC compared to 24% with SOC. With POC, losses to follow‐up were reduced by 41%. In the Addiction Centres, 12,566 users (91%) were screened using the two strategies. Compared to the SOC, POC increased access to treatment and linkage to care by 19% along with SVR at the same rate. Reinfection rates decreased by 6%. Thus, the implementation of a POC “test and treat” strategy at HRCs and Addiction Centres has shown to be an effective public health strategy to help eliminating HCV in accordance with WHO goal. John Wiley and Sons Inc. 2021-11-29 2022-03 /pmc/articles/PMC9299793/ /pubmed/34806812 http://dx.doi.org/10.1111/jvh.13634 Text en © 2021 The Authors. Journal of Viral Hepatitis published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Forns, Xavier Colom, Joan García‐Retortillo, Montse Quer, Joan Carles Lens, Sabela Martró, Elisa Domínguez‐Hernández, Raquel Casado, Miguel Ángel Buti, María Point‐of‐care hepatitis C testing and treatment strategy for people attending harm reduction and addiction centres for hepatitis C elimination |
title | Point‐of‐care hepatitis C testing and treatment strategy for people attending harm reduction and addiction centres for hepatitis C elimination |
title_full | Point‐of‐care hepatitis C testing and treatment strategy for people attending harm reduction and addiction centres for hepatitis C elimination |
title_fullStr | Point‐of‐care hepatitis C testing and treatment strategy for people attending harm reduction and addiction centres for hepatitis C elimination |
title_full_unstemmed | Point‐of‐care hepatitis C testing and treatment strategy for people attending harm reduction and addiction centres for hepatitis C elimination |
title_short | Point‐of‐care hepatitis C testing and treatment strategy for people attending harm reduction and addiction centres for hepatitis C elimination |
title_sort | point‐of‐care hepatitis c testing and treatment strategy for people attending harm reduction and addiction centres for hepatitis c elimination |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299793/ https://www.ncbi.nlm.nih.gov/pubmed/34806812 http://dx.doi.org/10.1111/jvh.13634 |
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