Conformational fingerprinting of allosteric modulators in metabotropic glutamate receptor 2

Activation of G protein-coupled receptors (GPCRs) is an allosteric process. It involves conformational coupling between the orthosteric ligand binding site and the G protein binding site. Factors that bind at non-cognate ligand binding sites to alter the allosteric activation process are classified...

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Detalles Bibliográficos
Autores principales: Liauw, Brandon Wey-Hung, Foroutan, Arash, Schamber, Michael R, Lu, Weifeng, Samareh Afsari, Hamid, Vafabakhsh, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299836/
https://www.ncbi.nlm.nih.gov/pubmed/35775730
http://dx.doi.org/10.7554/eLife.78982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299836/
https://www.ncbi.nlm.nih.gov/pubmed/35775730
http://dx.doi.org/10.7554/eLife.78982

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