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Conventional rigid 2D substrates cause complex contractile signals in monolayers of human induced pluripotent stem cell‐derived cardiomyocytes

ABSTRACT: Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CM) in monolayers interact mechanically via cell–cell and cell–substrate adhesion. Spatiotemporal features of contraction were analysed in hiPSC‐CM monolayers (1) attached to glass or plastic (Young's modulus (E) >1...

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Detalles Bibliográficos
Autores principales:	Huethorst, Eline, Mortensen, Peter, Simitev, Radostin D., Gao, Hao, Pohjolainen, Lotta, Talman, Virpi, Ruskoaho, Heikki, Burton, Francis L., Gadegaard, Nikolaj, Smith, Godfrey L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Cardiovascular
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299844/ https://www.ncbi.nlm.nih.gov/pubmed/34761809 http://dx.doi.org/10.1113/JP282228

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