Safety, Pharmacokinetics, and Pharmacodynamics of the ADAMTS‐5 Inhibitor GLPG1972/S201086 in Healthy Volunteers and Participants With Osteoarthritis of the Knee or Hip

GLPG1972/S201086 is a disintegrin and metalloproteinase with thrombospondin motif‐5 (ADAMTS‐5) inhibitor in development as an osteoarthritis disease‐modifying therapy. We report the safety, tolerability, pharmacokinetics, and pharmacodynamics (turnover of plasma/serum ARGS‐aggrecan neoepitope fragme...

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Detalles Bibliográficos
Autores principales: van der Aar, Ellen, Deckx, Henri, Dupont, Sonia, Fieuw, Ann, Delage, Stephane, Larsson, Staffan, Struglics, André, Lohmander, L. Stefan, Lalande, Agnes, Leroux, Emilie, Amantini, David, Passier, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299907/
https://www.ncbi.nlm.nih.gov/pubmed/34859612
http://dx.doi.org/10.1002/cpdd.1042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299907/
https://www.ncbi.nlm.nih.gov/pubmed/34859612
http://dx.doi.org/10.1002/cpdd.1042

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