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A CT‐less approach to quantitative PET imaging using the LSO intrinsic radiation for long‐axial FOV PET scanners
PURPOSE: Long‐axial field‐of‐view (FOV) positron emission tomography (PET) scanners have gained a lot of interest in the recent years. Such scanners provide increased sensitivity and enable unique imaging opportunities that were not previously feasible. Benefiting from the high sensitivity of a long...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299938/ https://www.ncbi.nlm.nih.gov/pubmed/34818446 http://dx.doi.org/10.1002/mp.15376 |
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author | Teimoorisichani, Mohammadreza Panin, Vladimir Rothfuss, Harold Sari, Hasan Rominger, Axel Conti, Maurizio |
author_facet | Teimoorisichani, Mohammadreza Panin, Vladimir Rothfuss, Harold Sari, Hasan Rominger, Axel Conti, Maurizio |
author_sort | Teimoorisichani, Mohammadreza |
collection | PubMed |
description | PURPOSE: Long‐axial field‐of‐view (FOV) positron emission tomography (PET) scanners have gained a lot of interest in the recent years. Such scanners provide increased sensitivity and enable unique imaging opportunities that were not previously feasible. Benefiting from the high sensitivity of a long‐axial FOV PET scanner, we studied a computed tomography (CT)–less reconstruction algorithm for the Siemens Biograph Vision Quadra with an axial FOV of 106 cm. METHODS: In this work, the background radiation from radioisotope lutetium‐176 in the scintillators was used to create an initial estimate of the attenuation maps. Then, joint activity and attenuation reconstruction algorithms were used to create an improved attenuation map of the object. The final attenuation maps were then used to reconstruct quantitative PET images, which were compared against CT‐based PET images. The proposed method was evaluated on data from three patients who underwent a flurodeoxyglucouse PET scan. RESULTS: Segmentation of the PET images of the three studied patients showed an average quantitative error of 6.5%–8.3% across all studied organs when using attenuation maps from maximum likelihood estimation of attenuation and activity and 5.3%–6.6% when using attenuation maps from maximum likelihood estimation of activity and attenuation correction coefficients. CONCLUSIONS: Benefiting from the background radiation of lutetium‐based scintillators, a quantitative CT‐less PET imaging technique was evaluated in this work. |
format | Online Article Text |
id | pubmed-9299938 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92999382022-07-21 A CT‐less approach to quantitative PET imaging using the LSO intrinsic radiation for long‐axial FOV PET scanners Teimoorisichani, Mohammadreza Panin, Vladimir Rothfuss, Harold Sari, Hasan Rominger, Axel Conti, Maurizio Med Phys QUANTITATIVE IMAGING AND IMAGE PROCESSING PURPOSE: Long‐axial field‐of‐view (FOV) positron emission tomography (PET) scanners have gained a lot of interest in the recent years. Such scanners provide increased sensitivity and enable unique imaging opportunities that were not previously feasible. Benefiting from the high sensitivity of a long‐axial FOV PET scanner, we studied a computed tomography (CT)–less reconstruction algorithm for the Siemens Biograph Vision Quadra with an axial FOV of 106 cm. METHODS: In this work, the background radiation from radioisotope lutetium‐176 in the scintillators was used to create an initial estimate of the attenuation maps. Then, joint activity and attenuation reconstruction algorithms were used to create an improved attenuation map of the object. The final attenuation maps were then used to reconstruct quantitative PET images, which were compared against CT‐based PET images. The proposed method was evaluated on data from three patients who underwent a flurodeoxyglucouse PET scan. RESULTS: Segmentation of the PET images of the three studied patients showed an average quantitative error of 6.5%–8.3% across all studied organs when using attenuation maps from maximum likelihood estimation of attenuation and activity and 5.3%–6.6% when using attenuation maps from maximum likelihood estimation of activity and attenuation correction coefficients. CONCLUSIONS: Benefiting from the background radiation of lutetium‐based scintillators, a quantitative CT‐less PET imaging technique was evaluated in this work. John Wiley and Sons Inc. 2021-12-10 2022-01 /pmc/articles/PMC9299938/ /pubmed/34818446 http://dx.doi.org/10.1002/mp.15376 Text en © 2021 Siemens Medical Solutions USA, Inc. Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | QUANTITATIVE IMAGING AND IMAGE PROCESSING Teimoorisichani, Mohammadreza Panin, Vladimir Rothfuss, Harold Sari, Hasan Rominger, Axel Conti, Maurizio A CT‐less approach to quantitative PET imaging using the LSO intrinsic radiation for long‐axial FOV PET scanners |
title | A CT‐less approach to quantitative PET imaging using the LSO intrinsic radiation for long‐axial FOV PET scanners |
title_full | A CT‐less approach to quantitative PET imaging using the LSO intrinsic radiation for long‐axial FOV PET scanners |
title_fullStr | A CT‐less approach to quantitative PET imaging using the LSO intrinsic radiation for long‐axial FOV PET scanners |
title_full_unstemmed | A CT‐less approach to quantitative PET imaging using the LSO intrinsic radiation for long‐axial FOV PET scanners |
title_short | A CT‐less approach to quantitative PET imaging using the LSO intrinsic radiation for long‐axial FOV PET scanners |
title_sort | ct‐less approach to quantitative pet imaging using the lso intrinsic radiation for long‐axial fov pet scanners |
topic | QUANTITATIVE IMAGING AND IMAGE PROCESSING |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299938/ https://www.ncbi.nlm.nih.gov/pubmed/34818446 http://dx.doi.org/10.1002/mp.15376 |
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