Substrate‐Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors

Extracellular virulence factors have emerged as attractive targets in the current antimicrobial resistance crisis. The Gram‐negative pathogen Pseudomonas aeruginosa secretes the virulence factor elastase B (LasB), which plays an important role in the infection process. Here, we report a sub‐micromol...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaya, Cansu, Walter, Isabell, Yahiaoui, Samir, Sikandar, Asfandyar, Alhayek, Alaa, Konstantinović, Jelena, Kany, Andreas M., Haupenthal, Jörg, Köhnke, Jesko, Hartmann, Rolf W., Hirsch, Anna K. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299988/
https://www.ncbi.nlm.nih.gov/pubmed/34762767
http://dx.doi.org/10.1002/anie.202112295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299988/
https://www.ncbi.nlm.nih.gov/pubmed/34762767
http://dx.doi.org/10.1002/anie.202112295

Ejemplares similares