A rare case of drug‐induced bradycardia associated with the just low dose use of methylprednisolone in a child with COVID‐19

Methylprednisolone (MP) is usually used to reduce inflammation reaction and tissue damage, which may have a beneficial treatment effect on coronavirus disease 2019 (COVID‐19). However, we present the case of a child who manifests significant bradycardia with the use of just low dose MP on the premis...

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Autores principales: Jiang, Ping, Wu, Shuang‐hua, Zhu, Ting, Guo, Yuan, He, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300027/
https://www.ncbi.nlm.nih.gov/pubmed/34911144
http://dx.doi.org/10.1002/jmv.27525
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author Jiang, Ping
Wu, Shuang‐hua
Zhu, Ting
Guo, Yuan
He, Yi
author_facet Jiang, Ping
Wu, Shuang‐hua
Zhu, Ting
Guo, Yuan
He, Yi
author_sort Jiang, Ping
collection PubMed
description Methylprednisolone (MP) is usually used to reduce inflammation reaction and tissue damage, which may have a beneficial treatment effect on coronavirus disease 2019 (COVID‐19). However, we present the case of a child who manifests significant bradycardia with the use of just low dose MP on the premise of the long‐term use of arbidol. Arbidol can affect the activity of CYP3A4, which is also a key metabolic enzyme of MP by competitive inhibition, and which is easy to aggravate the side effects of MP. Therefore, more attention should be paid to bradycardia occurrence in the patient with COVID‐19 when MP is considered in COVID‐19.
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spelling pubmed-93000272022-07-21 A rare case of drug‐induced bradycardia associated with the just low dose use of methylprednisolone in a child with COVID‐19 Jiang, Ping Wu, Shuang‐hua Zhu, Ting Guo, Yuan He, Yi J Med Virol Short Communication Methylprednisolone (MP) is usually used to reduce inflammation reaction and tissue damage, which may have a beneficial treatment effect on coronavirus disease 2019 (COVID‐19). However, we present the case of a child who manifests significant bradycardia with the use of just low dose MP on the premise of the long‐term use of arbidol. Arbidol can affect the activity of CYP3A4, which is also a key metabolic enzyme of MP by competitive inhibition, and which is easy to aggravate the side effects of MP. Therefore, more attention should be paid to bradycardia occurrence in the patient with COVID‐19 when MP is considered in COVID‐19. John Wiley and Sons Inc. 2021-12-20 2022-04 /pmc/articles/PMC9300027/ /pubmed/34911144 http://dx.doi.org/10.1002/jmv.27525 Text en © 2021 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Jiang, Ping
Wu, Shuang‐hua
Zhu, Ting
Guo, Yuan
He, Yi
A rare case of drug‐induced bradycardia associated with the just low dose use of methylprednisolone in a child with COVID‐19
title A rare case of drug‐induced bradycardia associated with the just low dose use of methylprednisolone in a child with COVID‐19
title_full A rare case of drug‐induced bradycardia associated with the just low dose use of methylprednisolone in a child with COVID‐19
title_fullStr A rare case of drug‐induced bradycardia associated with the just low dose use of methylprednisolone in a child with COVID‐19
title_full_unstemmed A rare case of drug‐induced bradycardia associated with the just low dose use of methylprednisolone in a child with COVID‐19
title_short A rare case of drug‐induced bradycardia associated with the just low dose use of methylprednisolone in a child with COVID‐19
title_sort rare case of drug‐induced bradycardia associated with the just low dose use of methylprednisolone in a child with covid‐19
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300027/
https://www.ncbi.nlm.nih.gov/pubmed/34911144
http://dx.doi.org/10.1002/jmv.27525
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