Amitriptyline blocks innate immune responses mediated by toll‐like receptor 4 and IL‐1 receptor: Preclinical and clinical evidence in osteoarthritis and gout

BACKGROUND AND PURPOSE: Osteoarthritis, a major cause of disability in developed countries does not have effective treatment. Activation of TLR4 and innate immune response factors contribute to osteoarthritis progressive cartilage degradation. There are no clinically available TLR4 inhibitors. Inter...

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Detalles Bibliográficos
Autores principales: Franco‐Trepat, Eloi, Alonso‐Pérez, Ana, Guillán‐Fresco, María, Jorge‐Mora, Alberto, Crespo‐Golmar, Antia, López‐Fagúndez, Miriam, Pazos‐Pérez, Andrés, Gualillo, Oreste, Belén Bravo, Susana, Gómez Bahamonde, Rodolfo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300168/
https://www.ncbi.nlm.nih.gov/pubmed/34643941
http://dx.doi.org/10.1111/bph.15707

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