Cargando…
Validation of a new combined transcutaneous tcPCO(2) and tcPO(2) sensor in children in the operating theater
BACKGROUND: Arterial blood gas analysis is the gold standard for monitoring of P(a)CO(2) and PaO(2) during mechanical ventilation. However, continuous measurements would be preferred. Transcutaneous sensors continuously measure blood gases diffusing from the locally heated skin. These sensors have b...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300198/ https://www.ncbi.nlm.nih.gov/pubmed/34882905 http://dx.doi.org/10.1111/pan.14375 |
_version_ | 1784751157375139840 |
---|---|
author | van Wijk, Jan J. van Weteringen, Willem Hoeks, Sanne E. Staals, Lonneke M. |
author_facet | van Wijk, Jan J. van Weteringen, Willem Hoeks, Sanne E. Staals, Lonneke M. |
author_sort | van Wijk, Jan J. |
collection | PubMed |
description | BACKGROUND: Arterial blood gas analysis is the gold standard for monitoring of P(a)CO(2) and PaO(2) during mechanical ventilation. However, continuous measurements would be preferred. Transcutaneous sensors continuously measure blood gases diffusing from the locally heated skin. These sensors have been validated in children mostly in intensive care settings. Accuracy in children during general anesthesia is largely unknown. AIMS: We conducted a study in children undergoing general anesthesia to validate the use and to determine the accuracy of continuous transcutaneous measurements of the partial pressures of PCO(2) (tcPCO(2)) and PO(2) (tcPO(2)). METHODS: A prospective observational study in a tertiary care pediatric hospital in The Netherlands, from April to October 2018, in children aged 0–18 years undergoing general anesthesia. Patients were included when endotracheally intubated and provided with an arterial catheter for regular blood sampling. Patients with a gestational age <31 weeks, burn victims, and patients with skin disease were excluded. TcPCO(2) and tcPO(2) measurements were performed with a SenTec OxiVenT(™) sensor (SenTec AG). Accuracy was determined with an agreement analysis between arterial and transcutaneous PCO(2) and PO(2) values, and between arterial and endtidal PCO(2) (etCO(2)) values, according to Bland and Altman, accounting for multiple measurements per subject. RESULTS: We included 53 patients (median age 4.1 years, IQR 0.7–14.4 years) and retrieved 175 samples. TcPCO(2)‐P(a)CO(2) agreement analysis provided a bias of 0.06 kPa (limits of agreement (LOA) −1.18 to 1.31), the etCO(2)‐P(a)CO(2) agreement showed a bias of −0.31 kPa (LOA −1.38 to 0.76). Results of the tcPO(2)‐PaO(2) agreement showed a bias of 3.40 to 0.86* (mean tension) kPa. CONCLUSIONS: This study showed good agreement between P(a)CO(2) and tcPCO(2) in children of all ages during general anesthesia. Both transcutaneous and endtidal CO(2) measurements showed good accuracy. TcPO(2) is only accurate under 6 months of age. |
format | Online Article Text |
id | pubmed-9300198 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93001982022-07-21 Validation of a new combined transcutaneous tcPCO(2) and tcPO(2) sensor in children in the operating theater van Wijk, Jan J. van Weteringen, Willem Hoeks, Sanne E. Staals, Lonneke M. Paediatr Anaesth Research Reports BACKGROUND: Arterial blood gas analysis is the gold standard for monitoring of P(a)CO(2) and PaO(2) during mechanical ventilation. However, continuous measurements would be preferred. Transcutaneous sensors continuously measure blood gases diffusing from the locally heated skin. These sensors have been validated in children mostly in intensive care settings. Accuracy in children during general anesthesia is largely unknown. AIMS: We conducted a study in children undergoing general anesthesia to validate the use and to determine the accuracy of continuous transcutaneous measurements of the partial pressures of PCO(2) (tcPCO(2)) and PO(2) (tcPO(2)). METHODS: A prospective observational study in a tertiary care pediatric hospital in The Netherlands, from April to October 2018, in children aged 0–18 years undergoing general anesthesia. Patients were included when endotracheally intubated and provided with an arterial catheter for regular blood sampling. Patients with a gestational age <31 weeks, burn victims, and patients with skin disease were excluded. TcPCO(2) and tcPO(2) measurements were performed with a SenTec OxiVenT(™) sensor (SenTec AG). Accuracy was determined with an agreement analysis between arterial and transcutaneous PCO(2) and PO(2) values, and between arterial and endtidal PCO(2) (etCO(2)) values, according to Bland and Altman, accounting for multiple measurements per subject. RESULTS: We included 53 patients (median age 4.1 years, IQR 0.7–14.4 years) and retrieved 175 samples. TcPCO(2)‐P(a)CO(2) agreement analysis provided a bias of 0.06 kPa (limits of agreement (LOA) −1.18 to 1.31), the etCO(2)‐P(a)CO(2) agreement showed a bias of −0.31 kPa (LOA −1.38 to 0.76). Results of the tcPO(2)‐PaO(2) agreement showed a bias of 3.40 to 0.86* (mean tension) kPa. CONCLUSIONS: This study showed good agreement between P(a)CO(2) and tcPCO(2) in children of all ages during general anesthesia. Both transcutaneous and endtidal CO(2) measurements showed good accuracy. TcPO(2) is only accurate under 6 months of age. John Wiley and Sons Inc. 2021-12-15 2022-03 /pmc/articles/PMC9300198/ /pubmed/34882905 http://dx.doi.org/10.1111/pan.14375 Text en © 2021 The Authors. Pediatric Anesthesia published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Reports van Wijk, Jan J. van Weteringen, Willem Hoeks, Sanne E. Staals, Lonneke M. Validation of a new combined transcutaneous tcPCO(2) and tcPO(2) sensor in children in the operating theater |
title | Validation of a new combined transcutaneous tcPCO(2) and tcPO(2) sensor in children in the operating theater |
title_full | Validation of a new combined transcutaneous tcPCO(2) and tcPO(2) sensor in children in the operating theater |
title_fullStr | Validation of a new combined transcutaneous tcPCO(2) and tcPO(2) sensor in children in the operating theater |
title_full_unstemmed | Validation of a new combined transcutaneous tcPCO(2) and tcPO(2) sensor in children in the operating theater |
title_short | Validation of a new combined transcutaneous tcPCO(2) and tcPO(2) sensor in children in the operating theater |
title_sort | validation of a new combined transcutaneous tcpco(2) and tcpo(2) sensor in children in the operating theater |
topic | Research Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300198/ https://www.ncbi.nlm.nih.gov/pubmed/34882905 http://dx.doi.org/10.1111/pan.14375 |
work_keys_str_mv | AT vanwijkjanj validationofanewcombinedtranscutaneoustcpco2andtcpo2sensorinchildrenintheoperatingtheater AT vanweteringenwillem validationofanewcombinedtranscutaneoustcpco2andtcpo2sensorinchildrenintheoperatingtheater AT hoekssannee validationofanewcombinedtranscutaneoustcpco2andtcpo2sensorinchildrenintheoperatingtheater AT staalslonnekem validationofanewcombinedtranscutaneoustcpco2andtcpo2sensorinchildrenintheoperatingtheater |