Vectorial Catalysis in Surface‐Anchored Nanometer‐Sized Metal–Organic Frameworks‐Based Microfluidic Devices

Vectorial catalysis—controlling multi‐step reactions in a programmed sequence and by defined spatial localization in a microscale device—is an enticing goal in bio‐inspired catalysis research. However, translating concepts from natural cascade biocatalysis into artificial hierarchical chemical syste...

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Autores principales: Semrau, Anna Lisa, Stanley, Philip M., Huber, Dominik, Schuster, Michael, Albada, Bauke, Zuilhof, Han, Cokoja, Mirza, Fischer, Roland A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300199/
https://www.ncbi.nlm.nih.gov/pubmed/34825766
http://dx.doi.org/10.1002/anie.202115100
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author Semrau, Anna Lisa
Stanley, Philip M.
Huber, Dominik
Schuster, Michael
Albada, Bauke
Zuilhof, Han
Cokoja, Mirza
Fischer, Roland A.
author_facet Semrau, Anna Lisa
Stanley, Philip M.
Huber, Dominik
Schuster, Michael
Albada, Bauke
Zuilhof, Han
Cokoja, Mirza
Fischer, Roland A.
author_sort Semrau, Anna Lisa
collection PubMed
description Vectorial catalysis—controlling multi‐step reactions in a programmed sequence and by defined spatial localization in a microscale device—is an enticing goal in bio‐inspired catalysis research. However, translating concepts from natural cascade biocatalysis into artificial hierarchical chemical systems remains a challenge. Herein, we demonstrate integration of two different surface‐anchored nanometer‐sized metal–organic frameworks (MOFs) in a microfluidic device for modelling vectorial catalysis. Catalyst immobilization at defined sections along the microchannel and a two‐step cascade reaction was conducted with full conversion after 30 seconds and high turnover frequencies (TOF≈10(5) h(−1)).
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spelling pubmed-93001992022-07-21 Vectorial Catalysis in Surface‐Anchored Nanometer‐Sized Metal–Organic Frameworks‐Based Microfluidic Devices Semrau, Anna Lisa Stanley, Philip M. Huber, Dominik Schuster, Michael Albada, Bauke Zuilhof, Han Cokoja, Mirza Fischer, Roland A. Angew Chem Int Ed Engl Communications Vectorial catalysis—controlling multi‐step reactions in a programmed sequence and by defined spatial localization in a microscale device—is an enticing goal in bio‐inspired catalysis research. However, translating concepts from natural cascade biocatalysis into artificial hierarchical chemical systems remains a challenge. Herein, we demonstrate integration of two different surface‐anchored nanometer‐sized metal–organic frameworks (MOFs) in a microfluidic device for modelling vectorial catalysis. Catalyst immobilization at defined sections along the microchannel and a two‐step cascade reaction was conducted with full conversion after 30 seconds and high turnover frequencies (TOF≈10(5) h(−1)). John Wiley and Sons Inc. 2021-12-09 2022-02-14 /pmc/articles/PMC9300199/ /pubmed/34825766 http://dx.doi.org/10.1002/anie.202115100 Text en © 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Communications
Semrau, Anna Lisa
Stanley, Philip M.
Huber, Dominik
Schuster, Michael
Albada, Bauke
Zuilhof, Han
Cokoja, Mirza
Fischer, Roland A.
Vectorial Catalysis in Surface‐Anchored Nanometer‐Sized Metal–Organic Frameworks‐Based Microfluidic Devices
title Vectorial Catalysis in Surface‐Anchored Nanometer‐Sized Metal–Organic Frameworks‐Based Microfluidic Devices
title_full Vectorial Catalysis in Surface‐Anchored Nanometer‐Sized Metal–Organic Frameworks‐Based Microfluidic Devices
title_fullStr Vectorial Catalysis in Surface‐Anchored Nanometer‐Sized Metal–Organic Frameworks‐Based Microfluidic Devices
title_full_unstemmed Vectorial Catalysis in Surface‐Anchored Nanometer‐Sized Metal–Organic Frameworks‐Based Microfluidic Devices
title_short Vectorial Catalysis in Surface‐Anchored Nanometer‐Sized Metal–Organic Frameworks‐Based Microfluidic Devices
title_sort vectorial catalysis in surface‐anchored nanometer‐sized metal–organic frameworks‐based microfluidic devices
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300199/
https://www.ncbi.nlm.nih.gov/pubmed/34825766
http://dx.doi.org/10.1002/anie.202115100
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