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In Vivo Antiplasmodial Potential of the Leaf, Mesocarp, and Epicarp of the Raphia hookeri Plant in Mice Infected with Plasmodium berghei NK65

RESULTS: The presence of alkaloids, fats and oils, phenolic, and flavonoids was detected via the qualitative test which was confirmed from the result obtained from the GC-MS chromatogram of ethanolic leaves extract. The GC-MS chromatogram of the constituents analogous to the twenty peaks was analyze...

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Detalles Bibliográficos
Autores principales: Oluyori, Abimbola Peter, Nwonuma, Charles, Akpo, Theresa, Inyinbor, Adejumoke Abosede, Dada, Oluwasogo Adewumi, Oladeji, Oluwole Solomon, Ogunnupebi, Temitope Aminat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300302/
https://www.ncbi.nlm.nih.gov/pubmed/35873624
http://dx.doi.org/10.1155/2022/4129045
Descripción
Sumario:RESULTS: The presence of alkaloids, fats and oils, phenolic, and flavonoids was detected via the qualitative test which was confirmed from the result obtained from the GC-MS chromatogram of ethanolic leaves extract. The GC-MS chromatogram of the constituents analogous to the twenty peaks was analyzed as follows: dodecanoic acid (1.94%), 2-undecanone (3.42%), hexadecanoic acid (44.84%), oleic acid (7.45%), octadecanoic acid (8.41%), narcissidine (2.38%), 1-dotriacontanol (2.38%), α-sitosterol (2.02%), and lupeol (1.42%). The total phenolics and flavonoids of 118 and 23.3702 mg/g were analyzed in the leaves extract. The leave extract exhibited inhibitory activity of 73.49% against free radicals which could lead to inflammation. The extracts and chloroquine-treated groups showed significant decrease in percentage parasitaemia with pronounced activity observed in chloroquine groups. CONCLUSION: The curative and scavenging potencies of studied plant could be attributed to the metabolites analyzed and could guide the formulation of new pharmacophores against malaria infections and inflammations.