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ZSTK474 Sensitizes Glioblastoma to Temozolomide by Blocking Homologous Recombination Repair

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. Temozolomide (TMZ) is used as the standard chemotherapeutic agent for GBM but with limited success, and treatment failure is mainly due to tumor resistance. One of the leading causes of TMZ resistance is the upregulation...

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Detalles Bibliográficos
Autores principales:	Jiao, Wenhui, Zhu, Shan, Shao, Jingrong, Zhang, Xiaoliang, Xu, Yanglu, Zhang, Yixuan, Wang, Ran, Zhong, Yuxu, Kong, Dexin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300311/ https://www.ncbi.nlm.nih.gov/pubmed/35872860 http://dx.doi.org/10.1155/2022/8568528

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