Cargando…

A Novel Inhibitor INF 39 Promotes Osteogenesis via Blocking the NLRP3/IL-1β Axis

PURPOSE: A balance between osteoblasts and osteoclasts is essential to maintain skeletal integrity, regulating bone metabolism and bone remodeling. The nucleotide binding oligomerization domain, leucine-rich repeat and pyrin domain containing protein 3 (NLRP3) inflammasome is known as a cytosolic co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Wenxiang, Tang, Pan, Fan, Shunwu, Jiang, Xuesheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300331/ https://www.ncbi.nlm.nih.gov/pubmed/35872849 http://dx.doi.org/10.1155/2022/7250578

Ejemplares similares

The Effect of Oblique Lumbar Interbody Fusion Compared with Transforaminal Lumbar Interbody Fusion Combined with Enhanced Recovery after Surgery Program on Patients with Lumbar Degenerative Disease at Short-Term Follow-Up
por: Chen, Wenxiang, et al.
Publicado: (2021)

The emerging role of IMD 0354 on bone homeostasis by suppressing osteoclastogenesis and bone resorption, but without affecting bone formation
por: Chen, Wenxiang, et al.
Publicado: (2019)

INF-α and Ototoxicity
por: Sharifian, Mohammad Reza, et al.
Publicado: (2013)

P48 - Leptin, IL4, INFγ in obese asthmatic children
por: Youssef, Doaa, et al.
Publicado: (2014)

Koumine Suppresses IL-1β Secretion and Attenuates Inflammation Associated With Blocking ROS/NF-κB/NLRP3 Axis in Macrophages
por: Luo, Yufei, et al.
Publicado: (2021)

Serum levels of IL-17, IL-4, and INFγ in Serbian patients with early rheumatoid arthritis
por: Pavlovic, Voja, et al.
Publicado: (2014)

IL-6 and INF-γ levels in patients with brucellosis in severe epidemic region, Xinjiang, China
por: Lin, Zhi-Qiang, et al.
Publicado: (2020)

Sitagliptin Alleviates Radiation-Induced Intestinal Injury by Activating NRF2-Antioxidant Axis, Mitigating NLRP3 Inf--lammasome Activation, and Reversing Gut Microbiota Disorder
por: Huang, Shanshan, et al.
Publicado: (2022)

Inhibition of the NLRP3/IL‐1β axis protects against sepsis‐induced cardiomyopathy
por: Busch, Katharina, et al.
Publicado: (2021)

Diagnostic value of T-Spot TB combined with INF-γ and IL-27 in tuberculous pleurisy
por: Zhang, Meng, et al.
Publicado: (2018)

Immunomodulatory effect of an isolated fraction from Tinospora crispa on intracellular expression of INF-γ, IL-6 and IL-8
por: Abood, Walaa Najm, et al.
Publicado: (2014)

Resveratrol Protects against Sepsis-Associated Encephalopathy and Inhibits the NLRP3/IL-1β Axis in Microglia
por: Sui, Da-ming, et al.
Publicado: (2016)

The immunomodulatory effect of IL-4 accelerates bone substitute material-mediated osteogenesis in aged rats via NLRP3 inflammasome inhibition
por: Li, Duchenhui, et al.
Publicado: (2023)

Effects of the novel formin INF1 on ciliogenesis
por: Copeland, S, et al.
Publicado: (2015)

Tumor NLRP3-Derived IL-1β Drives the IL-6/STAT3 Axis Resulting in Sustained MDSC-Mediated Immunosuppression
por: Tengesdal, Isak W., et al.
Publicado: (2021)

Nanostructured Self-Assembly of Inverted Formin 2 (INF2) and F-Actin–INF2 Complexes Revealed by Atomic Force Microscopy
por: Sharma, Shivani, et al.
Publicado: (2014)

Quercetin and Bornyl Acetate Regulate T-Lymphocyte Subsets and INF-γ/IL-4 Ratio In Utero in Pregnant Mice
por: Wang, Xiaodan, et al.
Publicado: (2011)

Overexpression of Recombinant Human Beta Interferon (rhINF-β) in Periplasmic Space of Escherichia coli
por: Morowvat, Mohammad Hossein, et al.
Publicado: (2014)

Puerarin promotes osteogenesis and inhibits adipogenesis in vitro
por: Wang, Nan, et al.
Publicado: (2013)

IKKepsilon involvement in Tax-mediated activation of INF pathway
por: Cremonese, Giorgia, et al.
Publicado: (2011)

Pulmonary Artery Pseudoaneurysm Secondary to Lung Inf lammation
por: Ishimoto, Shinichirou, et al.
Publicado: (2018)

INF-01 Les Isolements : Actualites Et Perspectives
Publicado: (2005)

INfORM: Inference of NetwOrk Response Modules
por: Marwah, Veer Singh, et al.
Publicado: (2018)

Upregulation of INF-γ, IL-6, and IL-8 expression during replication of turkey coronavirus in nonepithelial cells obtained from Meleagris gallopavo
por: Cardoso, Tereza Cristina, et al.
Publicado: (2021)

Exogenous dsRNA-Induced Silencing of the Phytophthora infestans Elicitin Genes inf1 and inf4 Suppresses Its Pathogenicity on Potato Plants
por: Ivanov, Artemii A., et al.
Publicado: (2023)

Comparison of infiltration (INF) and inferior alveolar nerve block (IANB) injection techniques in bilateral therapeutic removal of mandibular premolars
por: Rajendran, Balamurugan, et al.
Publicado: (2021)

Epac1 Blocks NLRP3 Inflammasome to Reduce IL-1β in Retinal Endothelial Cells and Mouse Retinal Vasculature
por: Jiang, Youde, et al.
Publicado: (2017)

INF2 promotes the formation of detyrosinated microtubules necessary for centrosome reorientation in T cells
por: Andrés-Delgado, Laura, et al.
Publicado: (2012)

Idebenone Regulates Aβ and LPS-Induced Neurogliosis and Cognitive Function Through Inhibition of NLRP3 Inflammasome/IL-1β Axis Activation
por: Lee, Hyun-ju, et al.
Publicado: (2022)

The NLRP3 inflammasome – interleukin 1β axis in uveal melanoma
por: Correa, Victor S. M. C., et al.
Publicado: (2023)

Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer
por: Jin, Xiaofeng, et al.
Publicado: (2017)

Structure and function of the N-terminal extension of the formin INF2
por: Labat-de-Hoz, Leticia, et al.
Publicado: (2022)

Clinical and Pathological Heterogeneity in FSGS due to INF2 Mutations
por: Morales-Alvarez, Martha Catalina, et al.
Publicado: (2022)

NLRP3 inflammasome via IL-1β regulates PCSK9 secretion
por: Ding, Zufeng, et al.
Publicado: (2020)

Ex vivo conditioning with IL-12 decreases T cell sensitivity to intratumoral INF-γ-induced apoptosis following adoptive transfer
por: Diaz-Montero, C Marcela, et al.
Publicado: (2015)

FMDV Leader Protein Interacts with the NACHT and LRR Domains of NLRP3 to Promote IL-1β Production
por: Choudhury, Sk Mohiuddin, et al.
Publicado: (2021)

Laser cooling of InF, InCl and InH with an ab initio study
por: Yang, Rong, et al.
Publicado: (2019)

Retraction Note to: Upregulation of INF-γ, IL-6, and IL-8 expression during replication of turkey coronavirus in nonepithelial cells obtained from Meleagris gallopavo
por: Cristina Cardoso, Tereza, et al.
Publicado: (2022)

INF2‐ and FHOD‐related formins promote ovulation in the somatic gonad of C. elegans
por: Hegsted, Anna, et al.
Publicado: (2016)

Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis
por: Nishida, Keigo, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_cmm6jfd1ikoa8kvaql9dbi0p71