The Regulatory Role of Ferroptosis in Bone Homeostasis

Ferroptosis is an iron-dependent form of programmed cell death and an important type of biological catabolism. Through the action of divalent iron or ester oxygenase, ferroptosis can induce lipid peroxidation and cell death, regulating a variety of physiological processes. The role of ferroptosis in...

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Autores principales: Xiong, Yuan, Chen, Lang, Lin, Ze, Hu, Yiqiang, Panayi, Adriana C., Zhou, Wu, Sun, Yun, Cao, Faqi, Liu, Guodong, Dai, Guangdong, Mi, Bobin, Liu, Guohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300333/
https://www.ncbi.nlm.nih.gov/pubmed/35873534
http://dx.doi.org/10.1155/2022/3568597
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author Xiong, Yuan
Chen, Lang
Lin, Ze
Hu, Yiqiang
Panayi, Adriana C.
Zhou, Wu
Sun, Yun
Cao, Faqi
Liu, Guodong
Dai, Guangdong
Mi, Bobin
Liu, Guohui
author_facet Xiong, Yuan
Chen, Lang
Lin, Ze
Hu, Yiqiang
Panayi, Adriana C.
Zhou, Wu
Sun, Yun
Cao, Faqi
Liu, Guodong
Dai, Guangdong
Mi, Bobin
Liu, Guohui
author_sort Xiong, Yuan
collection PubMed
description Ferroptosis is an iron-dependent form of programmed cell death and an important type of biological catabolism. Through the action of divalent iron or ester oxygenase, ferroptosis can induce lipid peroxidation and cell death, regulating a variety of physiological processes. The role of ferroptosis in the modulation of bone homeostasis is a significant topic of interest. Herein, we review and discuss recent studies exploring the mechanisms and functions of ferroptosis in different bone-related cells, including mesenchymal stem cells, osteoblasts, osteoclasts, and osteocytes. The association between ferroptosis and disorders of bone homeostasis is also explored in this review. Overall, we aim to provide a detailed overview of ferroptosis, summarizing recent understanding on its role in regulation of bone physiology and bone disease pathogenesis.
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spelling pubmed-93003332022-07-21 The Regulatory Role of Ferroptosis in Bone Homeostasis Xiong, Yuan Chen, Lang Lin, Ze Hu, Yiqiang Panayi, Adriana C. Zhou, Wu Sun, Yun Cao, Faqi Liu, Guodong Dai, Guangdong Mi, Bobin Liu, Guohui Stem Cells Int Review Article Ferroptosis is an iron-dependent form of programmed cell death and an important type of biological catabolism. Through the action of divalent iron or ester oxygenase, ferroptosis can induce lipid peroxidation and cell death, regulating a variety of physiological processes. The role of ferroptosis in the modulation of bone homeostasis is a significant topic of interest. Herein, we review and discuss recent studies exploring the mechanisms and functions of ferroptosis in different bone-related cells, including mesenchymal stem cells, osteoblasts, osteoclasts, and osteocytes. The association between ferroptosis and disorders of bone homeostasis is also explored in this review. Overall, we aim to provide a detailed overview of ferroptosis, summarizing recent understanding on its role in regulation of bone physiology and bone disease pathogenesis. Hindawi 2022-07-13 /pmc/articles/PMC9300333/ /pubmed/35873534 http://dx.doi.org/10.1155/2022/3568597 Text en Copyright © 2022 Yuan Xiong et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Xiong, Yuan
Chen, Lang
Lin, Ze
Hu, Yiqiang
Panayi, Adriana C.
Zhou, Wu
Sun, Yun
Cao, Faqi
Liu, Guodong
Dai, Guangdong
Mi, Bobin
Liu, Guohui
The Regulatory Role of Ferroptosis in Bone Homeostasis
title The Regulatory Role of Ferroptosis in Bone Homeostasis
title_full The Regulatory Role of Ferroptosis in Bone Homeostasis
title_fullStr The Regulatory Role of Ferroptosis in Bone Homeostasis
title_full_unstemmed The Regulatory Role of Ferroptosis in Bone Homeostasis
title_short The Regulatory Role of Ferroptosis in Bone Homeostasis
title_sort regulatory role of ferroptosis in bone homeostasis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300333/
https://www.ncbi.nlm.nih.gov/pubmed/35873534
http://dx.doi.org/10.1155/2022/3568597
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