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Clinical Efficacy of Image-Guided Radiation Therapy for Cervical Cancer and Its Impact on Patients' Serum Tumor Markers and KPS Scores

OBJECTIVE: To assess the clinical efficacy of image-guided radiation therapy (IGRT) for cervical cancer and its impact on patients' serum tumor markers and Karnofsky Performance Status (KPS) scores. METHODS: Between August 2018 and July 2020, 94 patients with cervical cancer diagnosed and treat...

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Autores principales: You, Xin, Hou, Feng-Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300355/
https://www.ncbi.nlm.nih.gov/pubmed/35874637
http://dx.doi.org/10.1155/2022/8536554
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author You, Xin
Hou, Feng-Yan
author_facet You, Xin
Hou, Feng-Yan
author_sort You, Xin
collection PubMed
description OBJECTIVE: To assess the clinical efficacy of image-guided radiation therapy (IGRT) for cervical cancer and its impact on patients' serum tumor markers and Karnofsky Performance Status (KPS) scores. METHODS: Between August 2018 and July 2020, 94 patients with cervical cancer diagnosed and treated in our hospital were recruited and assigned via the random number table method to receive either IGRT (study group) or conventional radiotherapy (control group), with 47 cases to each group. The primary endpoint was clinical efficacy, and secondary endpoints included serum tumor markers levels and KPS scores. RESULTS: IGRT was associated with a significantly higher efficacy (97.87%) versus convention radiotherapy (74.46%) (P < 0.05). IGRT resulted in significantly lower levels of squamous cell carcinoma antigen (SCC-Ag), carcinoembryonic antigen (CEA), carbohydrate antigen 50 (CA50), and carbohydrate antigen 724 (CA724) versus conventional radiotherapy (P < 0.05). The eligible patients after IGRT showed significantly higher KPS scores versus conventional radiotherapy (P < 0.05). CONCLUSION: IGRT enhances the survival of patients with cervical cancer, lowers their serum tumor marker levels, and elevates the KPS scores. Further clinical trials are, however, required prior to clinical promotion.
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spelling pubmed-93003552022-07-21 Clinical Efficacy of Image-Guided Radiation Therapy for Cervical Cancer and Its Impact on Patients' Serum Tumor Markers and KPS Scores You, Xin Hou, Feng-Yan J Oncol Research Article OBJECTIVE: To assess the clinical efficacy of image-guided radiation therapy (IGRT) for cervical cancer and its impact on patients' serum tumor markers and Karnofsky Performance Status (KPS) scores. METHODS: Between August 2018 and July 2020, 94 patients with cervical cancer diagnosed and treated in our hospital were recruited and assigned via the random number table method to receive either IGRT (study group) or conventional radiotherapy (control group), with 47 cases to each group. The primary endpoint was clinical efficacy, and secondary endpoints included serum tumor markers levels and KPS scores. RESULTS: IGRT was associated with a significantly higher efficacy (97.87%) versus convention radiotherapy (74.46%) (P < 0.05). IGRT resulted in significantly lower levels of squamous cell carcinoma antigen (SCC-Ag), carcinoembryonic antigen (CEA), carbohydrate antigen 50 (CA50), and carbohydrate antigen 724 (CA724) versus conventional radiotherapy (P < 0.05). The eligible patients after IGRT showed significantly higher KPS scores versus conventional radiotherapy (P < 0.05). CONCLUSION: IGRT enhances the survival of patients with cervical cancer, lowers their serum tumor marker levels, and elevates the KPS scores. Further clinical trials are, however, required prior to clinical promotion. Hindawi 2022-07-13 /pmc/articles/PMC9300355/ /pubmed/35874637 http://dx.doi.org/10.1155/2022/8536554 Text en Copyright © 2022 Xin You and Feng-Yan Hou. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
You, Xin
Hou, Feng-Yan
Clinical Efficacy of Image-Guided Radiation Therapy for Cervical Cancer and Its Impact on Patients' Serum Tumor Markers and KPS Scores
title Clinical Efficacy of Image-Guided Radiation Therapy for Cervical Cancer and Its Impact on Patients' Serum Tumor Markers and KPS Scores
title_full Clinical Efficacy of Image-Guided Radiation Therapy for Cervical Cancer and Its Impact on Patients' Serum Tumor Markers and KPS Scores
title_fullStr Clinical Efficacy of Image-Guided Radiation Therapy for Cervical Cancer and Its Impact on Patients' Serum Tumor Markers and KPS Scores
title_full_unstemmed Clinical Efficacy of Image-Guided Radiation Therapy for Cervical Cancer and Its Impact on Patients' Serum Tumor Markers and KPS Scores
title_short Clinical Efficacy of Image-Guided Radiation Therapy for Cervical Cancer and Its Impact on Patients' Serum Tumor Markers and KPS Scores
title_sort clinical efficacy of image-guided radiation therapy for cervical cancer and its impact on patients' serum tumor markers and kps scores
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300355/
https://www.ncbi.nlm.nih.gov/pubmed/35874637
http://dx.doi.org/10.1155/2022/8536554
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