Metabolic changes associated with two endocrine abnormalities in dogs: elevated fructosamine and low thyroxine

INTRODUCTION: Metabolomics studies in canine endocrine abnormalities are sparse and basic information on these abnormalities must be generated. OBJECTIVES: To characterize the metabolic changes associated with elevated fructosamine, reflecting poor glycemic control, and low thyroxine, a thyroid horm...

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Autores principales: Ottka, Claudia, Puurunen, Jenni, Müller, Elisabeth, Weber, Corinna, Klein, Ruth, Lohi, Hannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300525/
https://www.ncbi.nlm.nih.gov/pubmed/35859216
http://dx.doi.org/10.1007/s11306-022-01917-4
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author Ottka, Claudia
Puurunen, Jenni
Müller, Elisabeth
Weber, Corinna
Klein, Ruth
Lohi, Hannes
author_facet Ottka, Claudia
Puurunen, Jenni
Müller, Elisabeth
Weber, Corinna
Klein, Ruth
Lohi, Hannes
author_sort Ottka, Claudia
collection PubMed
description INTRODUCTION: Metabolomics studies in canine endocrine abnormalities are sparse and basic information on these abnormalities must be generated. OBJECTIVES: To characterize the metabolic changes associated with elevated fructosamine, reflecting poor glycemic control, and low thyroxine, a thyroid hormone controlling metabolism. METHODS: Leftovers of clinical serum samples; 25 controls, 79 high fructosamine, and 47 low thyroxine, were analyzed using (1)H NMR and differences were evaluated using Firth logistic regression. RESULTS: Both high fructosamine and low thyroxine were associated with changes in concentrations of multiple metabolites, including glycoprotein acetyls and lipids. CONCLUSION: These findings suggest promising makers for further research and clinical validation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11306-022-01917-4.
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spelling pubmed-93005252022-07-22 Metabolic changes associated with two endocrine abnormalities in dogs: elevated fructosamine and low thyroxine Ottka, Claudia Puurunen, Jenni Müller, Elisabeth Weber, Corinna Klein, Ruth Lohi, Hannes Metabolomics Original Article INTRODUCTION: Metabolomics studies in canine endocrine abnormalities are sparse and basic information on these abnormalities must be generated. OBJECTIVES: To characterize the metabolic changes associated with elevated fructosamine, reflecting poor glycemic control, and low thyroxine, a thyroid hormone controlling metabolism. METHODS: Leftovers of clinical serum samples; 25 controls, 79 high fructosamine, and 47 low thyroxine, were analyzed using (1)H NMR and differences were evaluated using Firth logistic regression. RESULTS: Both high fructosamine and low thyroxine were associated with changes in concentrations of multiple metabolites, including glycoprotein acetyls and lipids. CONCLUSION: These findings suggest promising makers for further research and clinical validation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11306-022-01917-4. Springer US 2022-07-20 2022 /pmc/articles/PMC9300525/ /pubmed/35859216 http://dx.doi.org/10.1007/s11306-022-01917-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Ottka, Claudia
Puurunen, Jenni
Müller, Elisabeth
Weber, Corinna
Klein, Ruth
Lohi, Hannes
Metabolic changes associated with two endocrine abnormalities in dogs: elevated fructosamine and low thyroxine
title Metabolic changes associated with two endocrine abnormalities in dogs: elevated fructosamine and low thyroxine
title_full Metabolic changes associated with two endocrine abnormalities in dogs: elevated fructosamine and low thyroxine
title_fullStr Metabolic changes associated with two endocrine abnormalities in dogs: elevated fructosamine and low thyroxine
title_full_unstemmed Metabolic changes associated with two endocrine abnormalities in dogs: elevated fructosamine and low thyroxine
title_short Metabolic changes associated with two endocrine abnormalities in dogs: elevated fructosamine and low thyroxine
title_sort metabolic changes associated with two endocrine abnormalities in dogs: elevated fructosamine and low thyroxine
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300525/
https://www.ncbi.nlm.nih.gov/pubmed/35859216
http://dx.doi.org/10.1007/s11306-022-01917-4
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