Disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice

Dissociation of hyper-phosphorylated Tau from neuronal microtubules and its pathological aggregates, are hallmarks in the etiology of tauopathies. The Tau-microtubule interface is subject to polyglutamylation, a reversible posttranslational modification, increasing negative charge at tubulin C-termi...

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Detalles Bibliográficos
Autores principales: Hausrat, Torben Johann, Janiesch, Philipp C., Breiden, Petra, Lutz, David, Hoffmeister-Ullerich, Sabine, Hermans-Borgmeyer, Irm, Failla, Antonio Virgilio, Kneussel, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300677/
https://www.ncbi.nlm.nih.gov/pubmed/35858909
http://dx.doi.org/10.1038/s41467-022-31776-5

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