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Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community
We examined the association of serum s-adenosylmethionine (SAM), s-adenosylhomocysteine (SAH) (methionine metabolites), and their ratio on the risk of dementia and death in a community-dwelling population of older Japanese individuals. 1371 residents of Hisayama, Japan, aged 65 years or older and wi...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300687/ https://www.ncbi.nlm.nih.gov/pubmed/35859106 http://dx.doi.org/10.1038/s41598-022-16242-y |
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author | Mihara, Akane Ohara, Tomoyuki Hata, Jun Chen, Sanmei Honda, Takanori Tamrakar, Sonam Isa, Akiko Wang, Dongmei Shimizu, Kuniyoshi Katakura, Yoshinori Yonemoto, Koji Nakao, Tomohiro Kitazono, Takanari Ninomiya, Toshiharu |
author_facet | Mihara, Akane Ohara, Tomoyuki Hata, Jun Chen, Sanmei Honda, Takanori Tamrakar, Sonam Isa, Akiko Wang, Dongmei Shimizu, Kuniyoshi Katakura, Yoshinori Yonemoto, Koji Nakao, Tomohiro Kitazono, Takanari Ninomiya, Toshiharu |
author_sort | Mihara, Akane |
collection | PubMed |
description | We examined the association of serum s-adenosylmethionine (SAM), s-adenosylhomocysteine (SAH) (methionine metabolites), and their ratio on the risk of dementia and death in a community-dwelling population of older Japanese individuals. 1371 residents of Hisayama, Japan, aged 65 years or older and without dementia, were followed for a median of 10.2 years (2007–2017). We divided serum SAM, SAH, and SAM/SAH ratio into quartiles. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs) of serum SAM, SAH, and SAM/SAH ratio levels on the risk of a composite outcome of all-cause dementia or death, and each outcome. During the follow-up, 635 participants developed all-cause dementia and/or died, of which 379 participants developed dementia and 394 deaths occurred. The multivariable-adjusted HRs of the composite outcome decreased significantly with increasing serum SAM levels (P for trend = 0.01), while they increased significantly with higher serum SAH levels (P for trend = 0.03). Higher serum SAM/SAH ratio levels were significantly associated with a lower risk of the composite outcome (P for trend = 0.002), as well as with lower risk of each outcome. Our findings suggest that the balance of methionine metabolites may closely associate with the risk of dementia and death. |
format | Online Article Text |
id | pubmed-9300687 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-93006872022-07-22 Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community Mihara, Akane Ohara, Tomoyuki Hata, Jun Chen, Sanmei Honda, Takanori Tamrakar, Sonam Isa, Akiko Wang, Dongmei Shimizu, Kuniyoshi Katakura, Yoshinori Yonemoto, Koji Nakao, Tomohiro Kitazono, Takanari Ninomiya, Toshiharu Sci Rep Article We examined the association of serum s-adenosylmethionine (SAM), s-adenosylhomocysteine (SAH) (methionine metabolites), and their ratio on the risk of dementia and death in a community-dwelling population of older Japanese individuals. 1371 residents of Hisayama, Japan, aged 65 years or older and without dementia, were followed for a median of 10.2 years (2007–2017). We divided serum SAM, SAH, and SAM/SAH ratio into quartiles. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs) of serum SAM, SAH, and SAM/SAH ratio levels on the risk of a composite outcome of all-cause dementia or death, and each outcome. During the follow-up, 635 participants developed all-cause dementia and/or died, of which 379 participants developed dementia and 394 deaths occurred. The multivariable-adjusted HRs of the composite outcome decreased significantly with increasing serum SAM levels (P for trend = 0.01), while they increased significantly with higher serum SAH levels (P for trend = 0.03). Higher serum SAM/SAH ratio levels were significantly associated with a lower risk of the composite outcome (P for trend = 0.002), as well as with lower risk of each outcome. Our findings suggest that the balance of methionine metabolites may closely associate with the risk of dementia and death. Nature Publishing Group UK 2022-07-20 /pmc/articles/PMC9300687/ /pubmed/35859106 http://dx.doi.org/10.1038/s41598-022-16242-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Mihara, Akane Ohara, Tomoyuki Hata, Jun Chen, Sanmei Honda, Takanori Tamrakar, Sonam Isa, Akiko Wang, Dongmei Shimizu, Kuniyoshi Katakura, Yoshinori Yonemoto, Koji Nakao, Tomohiro Kitazono, Takanari Ninomiya, Toshiharu Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community |
title | Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community |
title_full | Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community |
title_fullStr | Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community |
title_full_unstemmed | Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community |
title_short | Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community |
title_sort | association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300687/ https://www.ncbi.nlm.nih.gov/pubmed/35859106 http://dx.doi.org/10.1038/s41598-022-16242-y |
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