Mechanism of threonine ADP-ribosylation of F-actin by a Tc toxin

Tc toxins deliver toxic enzymes into host cells by a unique injection mechanism. One of these enzymes is the actin ADP-ribosyltransferase TccC3, whose activity leads to the clustering of the cellular cytoskeleton and ultimately cell death. Here, we show in atomic detail how TccC3 modifies actin. We...

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Detalles Bibliográficos
Autores principales: Belyy, Alexander, Lindemann, Florian, Roderer, Daniel, Funk, Johanna, Bardiaux, Benjamin, Protze, Jonas, Bieling, Peter, Oschkinat, Hartmut, Raunser, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300711/
https://www.ncbi.nlm.nih.gov/pubmed/35858890
http://dx.doi.org/10.1038/s41467-022-31836-w

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