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Pulmonary Artery Enlargement: An Independent Risk Factor for Mortality in Patients Hospitalized With COVID-19

OBJECTIVE: To assess whether baseline pulmonary artery diameter (PAD), obtained from noncontrast nongated computed tomography (NCCT), can be associated with coronavirus disease 2019 (COVID-19) outcomes. PATIENTS AND METHODS: This is a retrospective study of patients hospitalized with COVID-19 admitt...

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Autores principales: Riachy, Moussa A., Ismail, Anis, Awali, Mohamad, Farah, Fadi, Haddad, Sara F., Kerbage, Anthony, Aoun, Noel, Sleilaty, Ghassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300717/
https://www.ncbi.nlm.nih.gov/pubmed/35880237
http://dx.doi.org/10.1016/j.mayocpiqo.2022.07.001
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author Riachy, Moussa A.
Ismail, Anis
Awali, Mohamad
Farah, Fadi
Haddad, Sara F.
Kerbage, Anthony
Aoun, Noel
Sleilaty, Ghassan
author_facet Riachy, Moussa A.
Ismail, Anis
Awali, Mohamad
Farah, Fadi
Haddad, Sara F.
Kerbage, Anthony
Aoun, Noel
Sleilaty, Ghassan
author_sort Riachy, Moussa A.
collection PubMed
description OBJECTIVE: To assess whether baseline pulmonary artery diameter (PAD), obtained from noncontrast nongated computed tomography (NCCT), can be associated with coronavirus disease 2019 (COVID-19) outcomes. PATIENTS AND METHODS: This is a retrospective study of patients hospitalized with COVID-19 admitted to Hôtel-Dieu de France university hospital (Beirut, Lebanon) between March 1, 2020 and March 1, 2021. Pulmonary artery diameter was measured at baseline NCCT. Various outcomes were assessed, including hospital length of stay, intensive care unit admission, invasive mechanical ventilation, mortality, and Post–COVID-19 Functional Status scale at discharge and at 2-month follow-up. RESULTS: Four hundred sixty-five patients underwent baseline NCCT, including 315 men (67.7%) with a mean age of 63.7±16 years. Baseline PAD was higher in critically ill patients admitted to the intensive care unit (mean difference, 0.8 mm; 95% CI, 0.4-1.59 mm) and those receiving invasive mechanical ventilation (mean difference, 1.1 mm; 95% CI, 0.11-2.04 mm). Pulmonary artery diameter at baseline correlated significantly with hospital length of stay (r=0.130; P=.005), discharge status (r=0.117; P=.023), and with Post–COVID-19 Functional Status scale at 2-month follow-up (r=0.121; P=.021). Moreover, multivariable logistic regression showed that a PAD of 24.5 mm and above independently predicted in-hospital all-cause mortality remained unaffected in patients with COVID-19 (odds ratio, 2.07; 95% CI, 1.05-4.09). CONCLUSION: Baseline PAD measurement using NCCT can be a useful prognostic parameter. Its measurement can help to identify early severe cases and adapt the initial management of patients hospitalized with COVID-19.
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spelling pubmed-93007172022-07-21 Pulmonary Artery Enlargement: An Independent Risk Factor for Mortality in Patients Hospitalized With COVID-19 Riachy, Moussa A. Ismail, Anis Awali, Mohamad Farah, Fadi Haddad, Sara F. Kerbage, Anthony Aoun, Noel Sleilaty, Ghassan Mayo Clin Proc Innov Qual Outcomes Original Article OBJECTIVE: To assess whether baseline pulmonary artery diameter (PAD), obtained from noncontrast nongated computed tomography (NCCT), can be associated with coronavirus disease 2019 (COVID-19) outcomes. PATIENTS AND METHODS: This is a retrospective study of patients hospitalized with COVID-19 admitted to Hôtel-Dieu de France university hospital (Beirut, Lebanon) between March 1, 2020 and March 1, 2021. Pulmonary artery diameter was measured at baseline NCCT. Various outcomes were assessed, including hospital length of stay, intensive care unit admission, invasive mechanical ventilation, mortality, and Post–COVID-19 Functional Status scale at discharge and at 2-month follow-up. RESULTS: Four hundred sixty-five patients underwent baseline NCCT, including 315 men (67.7%) with a mean age of 63.7±16 years. Baseline PAD was higher in critically ill patients admitted to the intensive care unit (mean difference, 0.8 mm; 95% CI, 0.4-1.59 mm) and those receiving invasive mechanical ventilation (mean difference, 1.1 mm; 95% CI, 0.11-2.04 mm). Pulmonary artery diameter at baseline correlated significantly with hospital length of stay (r=0.130; P=.005), discharge status (r=0.117; P=.023), and with Post–COVID-19 Functional Status scale at 2-month follow-up (r=0.121; P=.021). Moreover, multivariable logistic regression showed that a PAD of 24.5 mm and above independently predicted in-hospital all-cause mortality remained unaffected in patients with COVID-19 (odds ratio, 2.07; 95% CI, 1.05-4.09). CONCLUSION: Baseline PAD measurement using NCCT can be a useful prognostic parameter. Its measurement can help to identify early severe cases and adapt the initial management of patients hospitalized with COVID-19. Elsevier 2022-07-21 /pmc/articles/PMC9300717/ /pubmed/35880237 http://dx.doi.org/10.1016/j.mayocpiqo.2022.07.001 Text en © 2022 Published by Elsevier Inc on behalf of Mayo Foundation for Medical Education and Research. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Riachy, Moussa A.
Ismail, Anis
Awali, Mohamad
Farah, Fadi
Haddad, Sara F.
Kerbage, Anthony
Aoun, Noel
Sleilaty, Ghassan
Pulmonary Artery Enlargement: An Independent Risk Factor for Mortality in Patients Hospitalized With COVID-19
title Pulmonary Artery Enlargement: An Independent Risk Factor for Mortality in Patients Hospitalized With COVID-19
title_full Pulmonary Artery Enlargement: An Independent Risk Factor for Mortality in Patients Hospitalized With COVID-19
title_fullStr Pulmonary Artery Enlargement: An Independent Risk Factor for Mortality in Patients Hospitalized With COVID-19
title_full_unstemmed Pulmonary Artery Enlargement: An Independent Risk Factor for Mortality in Patients Hospitalized With COVID-19
title_short Pulmonary Artery Enlargement: An Independent Risk Factor for Mortality in Patients Hospitalized With COVID-19
title_sort pulmonary artery enlargement: an independent risk factor for mortality in patients hospitalized with covid-19
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300717/
https://www.ncbi.nlm.nih.gov/pubmed/35880237
http://dx.doi.org/10.1016/j.mayocpiqo.2022.07.001
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