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Mirabegron and solifenacin are effective for the management of the increased urinary frequency induced by psychological stress in female mice

Evidence to support the effectiveness of β3-adrenoceptor agonist mirabegron and anti-muscarinic solifenacin in the management of bladder dysfunction caused by psychological stress is lacking. This study investigates whether mirabegron or solifenacin reduces the bladder overactivity caused by water a...

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Autores principales: West, Eliza G., McDermott, Catherine, Chess-Williams, Russ, Sellers, Donna J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300733/
https://www.ncbi.nlm.nih.gov/pubmed/35858980
http://dx.doi.org/10.1038/s41598-022-16487-7
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author West, Eliza G.
McDermott, Catherine
Chess-Williams, Russ
Sellers, Donna J.
author_facet West, Eliza G.
McDermott, Catherine
Chess-Williams, Russ
Sellers, Donna J.
author_sort West, Eliza G.
collection PubMed
description Evidence to support the effectiveness of β3-adrenoceptor agonist mirabegron and anti-muscarinic solifenacin in the management of bladder dysfunction caused by psychological stress is lacking. This study investigates whether mirabegron or solifenacin reduces the bladder overactivity caused by water avoidance stress (WAS) in mice. Female mice were exposed to WAS for 1 h/day for 10 days and received either placebo, solifenacin or mirabegron in drinking water. Controls were age-matched without stress exposure. Voiding behaviour and functional isolated whole bladder responses during distension and in response to pharmacological agents and electrical field stimulation was investigated. Urinary frequency was significantly increased following stress. Mice treated with mirabegron or solifenacin displayed significantly fewer voiding events compared to the stressed mice, and voiding frequency in drug-treated animals was comparable to unstressed controls. The maximal contractile responses of bladders to carbachol were significantly enhanced by stress and reduced by mirabegron but not solifenacin. The frequency of phasic bladder contractions following stimulation with carbachol was significantly enhanced following stress and remained elevated in the mirabegron treated group. However, treatment with solifenacin significantly reduced the frequency of phasic contractions to unstressed control levels. Solifenacin and mirabegron are beneficial in reducing the overall voiding dysfunction caused by WAS in mice.
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spelling pubmed-93007332022-07-22 Mirabegron and solifenacin are effective for the management of the increased urinary frequency induced by psychological stress in female mice West, Eliza G. McDermott, Catherine Chess-Williams, Russ Sellers, Donna J. Sci Rep Article Evidence to support the effectiveness of β3-adrenoceptor agonist mirabegron and anti-muscarinic solifenacin in the management of bladder dysfunction caused by psychological stress is lacking. This study investigates whether mirabegron or solifenacin reduces the bladder overactivity caused by water avoidance stress (WAS) in mice. Female mice were exposed to WAS for 1 h/day for 10 days and received either placebo, solifenacin or mirabegron in drinking water. Controls were age-matched without stress exposure. Voiding behaviour and functional isolated whole bladder responses during distension and in response to pharmacological agents and electrical field stimulation was investigated. Urinary frequency was significantly increased following stress. Mice treated with mirabegron or solifenacin displayed significantly fewer voiding events compared to the stressed mice, and voiding frequency in drug-treated animals was comparable to unstressed controls. The maximal contractile responses of bladders to carbachol were significantly enhanced by stress and reduced by mirabegron but not solifenacin. The frequency of phasic bladder contractions following stimulation with carbachol was significantly enhanced following stress and remained elevated in the mirabegron treated group. However, treatment with solifenacin significantly reduced the frequency of phasic contractions to unstressed control levels. Solifenacin and mirabegron are beneficial in reducing the overall voiding dysfunction caused by WAS in mice. Nature Publishing Group UK 2022-07-20 /pmc/articles/PMC9300733/ /pubmed/35858980 http://dx.doi.org/10.1038/s41598-022-16487-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
West, Eliza G.
McDermott, Catherine
Chess-Williams, Russ
Sellers, Donna J.
Mirabegron and solifenacin are effective for the management of the increased urinary frequency induced by psychological stress in female mice
title Mirabegron and solifenacin are effective for the management of the increased urinary frequency induced by psychological stress in female mice
title_full Mirabegron and solifenacin are effective for the management of the increased urinary frequency induced by psychological stress in female mice
title_fullStr Mirabegron and solifenacin are effective for the management of the increased urinary frequency induced by psychological stress in female mice
title_full_unstemmed Mirabegron and solifenacin are effective for the management of the increased urinary frequency induced by psychological stress in female mice
title_short Mirabegron and solifenacin are effective for the management of the increased urinary frequency induced by psychological stress in female mice
title_sort mirabegron and solifenacin are effective for the management of the increased urinary frequency induced by psychological stress in female mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300733/
https://www.ncbi.nlm.nih.gov/pubmed/35858980
http://dx.doi.org/10.1038/s41598-022-16487-7
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