Cargando…

Transcriptome Analysis of Tumor-Infiltrating Lymphocytes Identifies NK Cell Gene Signatures Associated With Lymphocyte Infiltration and Survival in Soft Tissue Sarcomas

PURPOSE: Clinical successes using current T-cell based immunotherapies have been limited in soft tissue sarcomas (STS), while pre-clinical studies have shown evidence of natural killer (NK) cell activity. Since tumor immune infiltration, especially tumor-infiltrating lymphocytes, is associated with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Judge, Sean J., Bloomstein, Joshua D., Sholevar, Cyrus J., Darrow, Morgan A., Stoffel, Kevin M., Vick, Logan V., Dunai, Cordelia, Cruz, Sylvia M., Razmara, Aryana M., Monjazeb, Arta M., Rebhun, Robert B., Murphy, William J., Canter, Robert J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300876/ https://www.ncbi.nlm.nih.gov/pubmed/35874727 http://dx.doi.org/10.3389/fimmu.2022.893177

Ejemplares similares

Analysis of tumor-infiltrating NK and T cells highlights IL-15 stimulation and TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas
por: Judge, Sean J, et al.
Publicado: (2020)

Intratumoral NKp46(+) natural killer cells are spatially distanced from T and MHC-I(+) cells with prognostic implications in soft tissue sarcoma
por: Cruz, Sylvia M., et al.
Publicado: (2023)

Natural Killer and T Cell Infiltration in Canine Osteosarcoma: Clinical Implications and Translational Relevance
por: Razmara, Aryana M., et al.
Publicado: (2021)

Mouse Preclinical Cancer Immunotherapy Modeling Involving Anti-PD-1 Therapies Reveals the Need to Use Mouse Reagents to Mirror Clinical Paradigms
por: Monjazeb, Arta M., et al.
Publicado: (2021)

Aging augments obesity-induced thymic involution and peripheral T cell exhaustion altering the “obesity paradox”
por: Vick, Logan V., et al.
Publicado: (2023)

Missing a “Missing Self” Mechanism: Modeling and Detection of Ly49 Expression in Canine NK Cells
por: Gingrich, Alicia A., et al.
Publicado: (2023)

Regulation of human and mouse bystander T cell activation responses by PD-1
por: Le, Catherine T., et al.
Publicado: (2023)

Mechanisms by Which Obesity Promotes Acute Graft-Versus-Host Disease in Mice
por: Khuat, Lam T., et al.
Publicado: (2021)

PD-1 Blockade Reverses Obesity-Mediated T Cell Priming Impairment
por: Le, Catherine T., et al.
Publicado: (2020)

Human soft tissue sarcomas harbor an intratumoral viral microbiome which is linked with natural killer cell infiltrate and prognosis
por: Perry, Lauren M, et al.
Publicado: (2023)

Tumor-infiltrating lymphocyte: features and prognosis of lymphocytes infiltration on colorectal cancer
por: Qin, Miao, et al.
Publicado: (2023)

T Cell Immune Profiles of Blood and Tumor in Dogs Diagnosed With Malignant Melanoma
por: Sparger, Ellen E., et al.
Publicado: (2021)

The Significance of Lymphocytic Infiltration in Neuroblastoma
por: Lauder, I., et al.
Publicado: (1972)

Comparative Immunogenomics of Canine Natural Killer Cells as Immunotherapy Target
por: Gingrich, Alicia A., et al.
Publicado: (2021)

Activation status dictates the function of unlicensed natural killer cells in mice and humans
por: Aguilar, Ethan G., et al.
Publicado: (2021)

Parathyroid Adenoma with Prominent Lymphocytic Infiltrate
por: Iliadis, Alexandros, et al.
Publicado: (2015)

The role of tumor-infiltrating lymphocytes in cholangiocarcinoma
por: Liu, Dong, et al.
Publicado: (2022)

Three Cases of Lymphocytic Infiltration of the Eyelid
por: Sugioka, Kyoko, et al.
Publicado: (2021)

Tumor-infiltrating lymphocytes for melanoma immunotherapy
por: Kepp, Oliver, et al.
Publicado: (2023)

S47. Tumour infiltrating lymphocytes - a predictive marker?
por: Galon, J
Publicado: (2014)

The integrative clinical impact of tumor-infiltrating T lymphocytes and NK cells in relation to B lymphocyte and plasma cell density in esophageal and gastric adenocarcinoma
por: Svensson, Maria C., et al.
Publicado: (2017)

Tumor-Infiltrating Lymphocytes and Their Prognostic Value in Cutaneous Melanoma
por: Maibach, Fabienne, et al.
Publicado: (2020)

Tumor infiltrating lymphocytes as an endpoint in cancer vaccine trials
por: McCarthy, Patrick M., et al.
Publicado: (2023)

Lymphocytes infiltrating human breast cancers lack K-cell activity and show low levels of NK-cell activity.
por: Eremin, O., et al.
Publicado: (1981)

Ways to Enhance Lymphocyte Trafficking into Tumors and Fitness of Tumor Infiltrating Lymphocytes
por: Bellone, Matteo, et al.
Publicado: (2013)

Using the canine microbiome to bridge translation of cancer immunotherapy from pre-clinical murine models to human clinical trials
por: Kleber, Kara T., et al.
Publicado: (2022)

Tumour-infiltrating lymphocytes predict for outcome in HPV-positive oropharyngeal cancer
por: Ward, M J, et al.
Publicado: (2014)

Generating CAR T cells from tumor-infiltrating lymphocytes
por: Mills, Jane K., et al.
Publicado: (2021)

Relevance of tumor-infiltrating lymphocytes in breast cancer
por: Dushyanthen, Sathana, et al.
Publicado: (2015)

Infiltrating Lymphocytes and Accessory Cells in Nasopharyngeal Carcinoma
por: Zong, Yong‐sheng, et al.
Publicado: (1993)

Gingival Leukemic Infiltration in Chronic Lymphocytic Leukemia
por: Kacem, Karima, et al.
Publicado: (2019)

Tumor infiltrating lymphocytes and radiological picture of the tumor
por: Frankowska, Karolina, et al.
Publicado: (2023)

Vulval superficial myofibroblastoma with lymphocytic and eosinophilic infiltrate
por: Tan, Qi Ting, et al.
Publicado: (2023)

Characterizing the Dysfunctional NK Cell: Assessing the Clinical Relevance of Exhaustion, Anergy, and Senescence
por: Judge, Sean J., et al.
Publicado: (2020)

Expansion of tumor infiltrating lymphocytes (TIL) from bladder cancer
por: Poch, Michael, et al.
Publicado: (2018)

Spatial Characterization of Tumor-Infiltrating Lymphocytes and Breast Cancer Progression
por: Fassler, Danielle J., et al.
Publicado: (2022)

Combination radioimmunotherapy with adoptive NK transfer targets cancer stem cells in canine models of bone and soft tissue sarcoma
por: Canter, Robert, et al.
Publicado: (2015)

The type of lymphocyte infiltration near urothelial carcinoma is diagnostic for chronic lymphocytic leukemia
por: Baseskiogulu, Barbaros, et al.
Publicado: (2013)

Identification of genes and pathways associated with cytotoxic T lymphocyte infiltration of serous ovarian cancer
por: Leffers, N, et al.
Publicado: (2010)

Prognostic implications of type and density of tumour-infiltrating lymphocytes in gastric cancer
por: Lee, H E, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_qdbjgh75gjdon4ls891780796h