Interaction Between Intrinsic Renal Cells and Immune Cells in the Progression of Acute Kidney Injury

A growing number of studies have confirmed that immune cells play various key roles in the pathophysiology of acute kidney injury (AKI) development. After the resident immune cells and intrinsic renal cells are damaged by ischemia and hypoxia, drugs and toxins, more immune cells will be recruited to...

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Autores principales: Deng, Junhui, Wu, Zhifen, He, Yun, Lin, Lirong, Tan, Wei, Yang, Jurong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300888/
https://www.ncbi.nlm.nih.gov/pubmed/35872775
http://dx.doi.org/10.3389/fmed.2022.954574
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author Deng, Junhui
Wu, Zhifen
He, Yun
Lin, Lirong
Tan, Wei
Yang, Jurong
author_facet Deng, Junhui
Wu, Zhifen
He, Yun
Lin, Lirong
Tan, Wei
Yang, Jurong
author_sort Deng, Junhui
collection PubMed
description A growing number of studies have confirmed that immune cells play various key roles in the pathophysiology of acute kidney injury (AKI) development. After the resident immune cells and intrinsic renal cells are damaged by ischemia and hypoxia, drugs and toxins, more immune cells will be recruited to infiltrate through the release of chemokines, while the intrinsic cells promote macrophage polarity conversion, and the immune cells will promote various programmed deaths, phenotypic conversion and cycle arrest of the intrinsic cells, ultimately leading to renal impairment and fibrosis. In the complex and dynamic immune microenvironment of AKI, the bidirectional interaction between immune cells and intrinsic renal cells affects the prognosis of the kidney and the progression of fibrosis, and determines the ultimate fate of the kidney.
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spelling pubmed-93008882022-07-22 Interaction Between Intrinsic Renal Cells and Immune Cells in the Progression of Acute Kidney Injury Deng, Junhui Wu, Zhifen He, Yun Lin, Lirong Tan, Wei Yang, Jurong Front Med (Lausanne) Medicine A growing number of studies have confirmed that immune cells play various key roles in the pathophysiology of acute kidney injury (AKI) development. After the resident immune cells and intrinsic renal cells are damaged by ischemia and hypoxia, drugs and toxins, more immune cells will be recruited to infiltrate through the release of chemokines, while the intrinsic cells promote macrophage polarity conversion, and the immune cells will promote various programmed deaths, phenotypic conversion and cycle arrest of the intrinsic cells, ultimately leading to renal impairment and fibrosis. In the complex and dynamic immune microenvironment of AKI, the bidirectional interaction between immune cells and intrinsic renal cells affects the prognosis of the kidney and the progression of fibrosis, and determines the ultimate fate of the kidney. Frontiers Media S.A. 2022-07-07 /pmc/articles/PMC9300888/ /pubmed/35872775 http://dx.doi.org/10.3389/fmed.2022.954574 Text en Copyright © 2022 Deng, Wu, He, Lin, Tan and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Deng, Junhui
Wu, Zhifen
He, Yun
Lin, Lirong
Tan, Wei
Yang, Jurong
Interaction Between Intrinsic Renal Cells and Immune Cells in the Progression of Acute Kidney Injury
title Interaction Between Intrinsic Renal Cells and Immune Cells in the Progression of Acute Kidney Injury
title_full Interaction Between Intrinsic Renal Cells and Immune Cells in the Progression of Acute Kidney Injury
title_fullStr Interaction Between Intrinsic Renal Cells and Immune Cells in the Progression of Acute Kidney Injury
title_full_unstemmed Interaction Between Intrinsic Renal Cells and Immune Cells in the Progression of Acute Kidney Injury
title_short Interaction Between Intrinsic Renal Cells and Immune Cells in the Progression of Acute Kidney Injury
title_sort interaction between intrinsic renal cells and immune cells in the progression of acute kidney injury
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300888/
https://www.ncbi.nlm.nih.gov/pubmed/35872775
http://dx.doi.org/10.3389/fmed.2022.954574
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