Mesial Temporal Lobe Epilepsy (MTLE) Drug-Refractoriness Is Associated With P2X7 Receptors Overexpression in the Human Hippocampus and Temporal Neocortex and May Be Predicted by Low Circulating Levels of miR-22

Objective: ATP-gated ionotropic P2X7 receptors (P2X7R) actively participate in epilepsy and other neurological disorders. Neocortical nerve terminals of patients with Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (MTLE-HS) express higher P2X7R amounts. Overexpression of P2X7R bolsters ATP...

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Detalles Bibliográficos
Autores principales: Guerra Leal, Bárbara, Barros-Barbosa, Aurora, Ferreirinha, Fátima, Chaves, João, Rangel, Rui, Santos, Agostinho, Carvalho, Cláudia, Martins-Ferreira, Ricardo, Samões, Raquel, Freitas, Joel, Lopes, João, Ramalheira, João, Lobo, Maria Graça, Martins da Silva, António, Costa, Paulo P., Correia-de-Sá, Paulo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300956/
https://www.ncbi.nlm.nih.gov/pubmed/35875355
http://dx.doi.org/10.3389/fncel.2022.910662

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