Cargando…

The Mechanism of Lung and Intestinal Injury in Acute Pancreatitis: A Review

Acute pancreatitis (AP), as a common cause of clinical acute abdomen, often leads to multi-organ damage. In the process of severe AP, the lungs and intestines are the most easily affected organs aside the pancreas. These organ damages occur in succession. Notably, lung and intestinal injuries are cl...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Dongling, Wen, Linlin, Wang, Zhandong, Hai, Yang, Yang, Dan, Zhang, Yanying, Bai, Min, Song, Bing, Wang, Yongfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301017/
https://www.ncbi.nlm.nih.gov/pubmed/35872761
http://dx.doi.org/10.3389/fmed.2022.904078
_version_ 1784751340733333504
author Liu, Dongling
Wen, Linlin
Wang, Zhandong
Hai, Yang
Yang, Dan
Zhang, Yanying
Bai, Min
Song, Bing
Wang, Yongfeng
author_facet Liu, Dongling
Wen, Linlin
Wang, Zhandong
Hai, Yang
Yang, Dan
Zhang, Yanying
Bai, Min
Song, Bing
Wang, Yongfeng
author_sort Liu, Dongling
collection PubMed
description Acute pancreatitis (AP), as a common cause of clinical acute abdomen, often leads to multi-organ damage. In the process of severe AP, the lungs and intestines are the most easily affected organs aside the pancreas. These organ damages occur in succession. Notably, lung and intestinal injuries are closely linked. Damage to ML, which transports immune cells, intestinal fluid, chyle, and toxic components (including toxins, trypsin, and activated cytokines to the systemic circulation in AP) may be connected to AP. This process can lead to the pathological changes of hyperosmotic edema of the lung, an increase in alveolar fluid level, destruction of the intestinal mucosal structure, and impairment of intestinal mucosal permeability. The underlying mechanisms of the correlation between lung and intestinal injuries are inflammatory response, oxidative stress, and endocrine hormone secretion disorders. The main signaling pathways of lung and intestinal injuries are TNF-α, HMGB1-mediated inflammation amplification effect of NF-κB signal pathway, Nrf2/ARE oxidative stress response signaling pathway, and IL-6-mediated JAK2/STAT3 signaling pathway. These pathways exert anti-inflammatory response and anti-oxidative stress, inhibit cell proliferation, and promote apoptosis. The interaction is consistent with the traditional Chinese medicine theory of the lung being connected with the large intestine (fei yu da chang xiang biao li in Chinese). This review sought to explore intersecting mechanisms of lung and intestinal injuries in AP to develop new treatment strategies.
format Online
Article
Text
id pubmed-9301017
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-93010172022-07-22 The Mechanism of Lung and Intestinal Injury in Acute Pancreatitis: A Review Liu, Dongling Wen, Linlin Wang, Zhandong Hai, Yang Yang, Dan Zhang, Yanying Bai, Min Song, Bing Wang, Yongfeng Front Med (Lausanne) Medicine Acute pancreatitis (AP), as a common cause of clinical acute abdomen, often leads to multi-organ damage. In the process of severe AP, the lungs and intestines are the most easily affected organs aside the pancreas. These organ damages occur in succession. Notably, lung and intestinal injuries are closely linked. Damage to ML, which transports immune cells, intestinal fluid, chyle, and toxic components (including toxins, trypsin, and activated cytokines to the systemic circulation in AP) may be connected to AP. This process can lead to the pathological changes of hyperosmotic edema of the lung, an increase in alveolar fluid level, destruction of the intestinal mucosal structure, and impairment of intestinal mucosal permeability. The underlying mechanisms of the correlation between lung and intestinal injuries are inflammatory response, oxidative stress, and endocrine hormone secretion disorders. The main signaling pathways of lung and intestinal injuries are TNF-α, HMGB1-mediated inflammation amplification effect of NF-κB signal pathway, Nrf2/ARE oxidative stress response signaling pathway, and IL-6-mediated JAK2/STAT3 signaling pathway. These pathways exert anti-inflammatory response and anti-oxidative stress, inhibit cell proliferation, and promote apoptosis. The interaction is consistent with the traditional Chinese medicine theory of the lung being connected with the large intestine (fei yu da chang xiang biao li in Chinese). This review sought to explore intersecting mechanisms of lung and intestinal injuries in AP to develop new treatment strategies. Frontiers Media S.A. 2022-07-07 /pmc/articles/PMC9301017/ /pubmed/35872761 http://dx.doi.org/10.3389/fmed.2022.904078 Text en Copyright © 2022 Liu, Wen, Wang, Hai, Yang, Zhang, Bai, Song and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Liu, Dongling
Wen, Linlin
Wang, Zhandong
Hai, Yang
Yang, Dan
Zhang, Yanying
Bai, Min
Song, Bing
Wang, Yongfeng
The Mechanism of Lung and Intestinal Injury in Acute Pancreatitis: A Review
title The Mechanism of Lung and Intestinal Injury in Acute Pancreatitis: A Review
title_full The Mechanism of Lung and Intestinal Injury in Acute Pancreatitis: A Review
title_fullStr The Mechanism of Lung and Intestinal Injury in Acute Pancreatitis: A Review
title_full_unstemmed The Mechanism of Lung and Intestinal Injury in Acute Pancreatitis: A Review
title_short The Mechanism of Lung and Intestinal Injury in Acute Pancreatitis: A Review
title_sort mechanism of lung and intestinal injury in acute pancreatitis: a review
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301017/
https://www.ncbi.nlm.nih.gov/pubmed/35872761
http://dx.doi.org/10.3389/fmed.2022.904078
work_keys_str_mv AT liudongling themechanismoflungandintestinalinjuryinacutepancreatitisareview
AT wenlinlin themechanismoflungandintestinalinjuryinacutepancreatitisareview
AT wangzhandong themechanismoflungandintestinalinjuryinacutepancreatitisareview
AT haiyang themechanismoflungandintestinalinjuryinacutepancreatitisareview
AT yangdan themechanismoflungandintestinalinjuryinacutepancreatitisareview
AT zhangyanying themechanismoflungandintestinalinjuryinacutepancreatitisareview
AT baimin themechanismoflungandintestinalinjuryinacutepancreatitisareview
AT songbing themechanismoflungandintestinalinjuryinacutepancreatitisareview
AT wangyongfeng themechanismoflungandintestinalinjuryinacutepancreatitisareview
AT liudongling mechanismoflungandintestinalinjuryinacutepancreatitisareview
AT wenlinlin mechanismoflungandintestinalinjuryinacutepancreatitisareview
AT wangzhandong mechanismoflungandintestinalinjuryinacutepancreatitisareview
AT haiyang mechanismoflungandintestinalinjuryinacutepancreatitisareview
AT yangdan mechanismoflungandintestinalinjuryinacutepancreatitisareview
AT zhangyanying mechanismoflungandintestinalinjuryinacutepancreatitisareview
AT baimin mechanismoflungandintestinalinjuryinacutepancreatitisareview
AT songbing mechanismoflungandintestinalinjuryinacutepancreatitisareview
AT wangyongfeng mechanismoflungandintestinalinjuryinacutepancreatitisareview