Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance

Atopic dermatitis (AD) is a chronic and relapsing cutaneous disorder characterized by compromised immune system, excessive inflammation, and skin barrier disruption. Post-translational modifications (PTMs) are covalent and enzymatic modifications of proteins after their translation, which have been...

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Autores principales: Ma, Xin, Ru, Yi, Luo, Ying, Kuai, Le, Chen, Qi-Long, Bai, Yun, Liu, Ye-Qiang, Chen, Jia, Luo, Yue, Song, Jian-Kun, Zhou, Mi, Li, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301047/
https://www.ncbi.nlm.nih.gov/pubmed/35874824
http://dx.doi.org/10.3389/fcell.2022.942838
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author Ma, Xin
Ru, Yi
Luo, Ying
Kuai, Le
Chen, Qi-Long
Bai, Yun
Liu, Ye-Qiang
Chen, Jia
Luo, Yue
Song, Jian-Kun
Zhou, Mi
Li, Bin
author_facet Ma, Xin
Ru, Yi
Luo, Ying
Kuai, Le
Chen, Qi-Long
Bai, Yun
Liu, Ye-Qiang
Chen, Jia
Luo, Yue
Song, Jian-Kun
Zhou, Mi
Li, Bin
author_sort Ma, Xin
collection PubMed
description Atopic dermatitis (AD) is a chronic and relapsing cutaneous disorder characterized by compromised immune system, excessive inflammation, and skin barrier disruption. Post-translational modifications (PTMs) are covalent and enzymatic modifications of proteins after their translation, which have been reported to play roles in inflammatory and allergic diseases. However, less attention has been paid to the effect of PTMs on AD. This review summarized the knowledge of six major classes (including phosphorylation, acetylation, ubiquitination, SUMOylation, glycosylation, o-glycosylation, and glycation) of PTMs in AD pathogenesis and discussed the opportunities for disease management.
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spelling pubmed-93010472022-07-22 Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance Ma, Xin Ru, Yi Luo, Ying Kuai, Le Chen, Qi-Long Bai, Yun Liu, Ye-Qiang Chen, Jia Luo, Yue Song, Jian-Kun Zhou, Mi Li, Bin Front Cell Dev Biol Cell and Developmental Biology Atopic dermatitis (AD) is a chronic and relapsing cutaneous disorder characterized by compromised immune system, excessive inflammation, and skin barrier disruption. Post-translational modifications (PTMs) are covalent and enzymatic modifications of proteins after their translation, which have been reported to play roles in inflammatory and allergic diseases. However, less attention has been paid to the effect of PTMs on AD. This review summarized the knowledge of six major classes (including phosphorylation, acetylation, ubiquitination, SUMOylation, glycosylation, o-glycosylation, and glycation) of PTMs in AD pathogenesis and discussed the opportunities for disease management. Frontiers Media S.A. 2022-07-07 /pmc/articles/PMC9301047/ /pubmed/35874824 http://dx.doi.org/10.3389/fcell.2022.942838 Text en Copyright © 2022 Ma, Ru, Luo, Kuai, Chen, Bai, Liu, Chen, Luo, Song, Zhou and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Ma, Xin
Ru, Yi
Luo, Ying
Kuai, Le
Chen, Qi-Long
Bai, Yun
Liu, Ye-Qiang
Chen, Jia
Luo, Yue
Song, Jian-Kun
Zhou, Mi
Li, Bin
Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance
title Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance
title_full Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance
title_fullStr Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance
title_full_unstemmed Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance
title_short Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance
title_sort post-translational modifications in atopic dermatitis: current research and clinical relevance
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301047/
https://www.ncbi.nlm.nih.gov/pubmed/35874824
http://dx.doi.org/10.3389/fcell.2022.942838
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