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Increased IL-31 expression in serum and tissue protein in prurigo nodularis

BACKGROUND: Prurigo nodularis (PN) is a chronic pruritic skin disease which can greatly impact patients’ quality of life. Moreover, the pathogenesis remains unclear, making it a difficult-to-treat condition. AIMS: To investigate the expression of interleukin-31 (IL-31) in serum and skin biopsy speci...

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Autores principales: Chaowattanapanit, Suteeraporn, Wongjirattikarn, Rachot, Chaisuriya, Nipon, Ungarreevittaya, Piti, Poosekeaw, Pirawan, Winaikosol, Kengkart, Choonhakarn, Charoen, Julanon, Narachai, Salao, Kanin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301099/
https://www.ncbi.nlm.nih.gov/pubmed/35875833
http://dx.doi.org/10.1177/20406223221112561
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author Chaowattanapanit, Suteeraporn
Wongjirattikarn, Rachot
Chaisuriya, Nipon
Ungarreevittaya, Piti
Poosekeaw, Pirawan
Winaikosol, Kengkart
Choonhakarn, Charoen
Julanon, Narachai
Salao, Kanin
author_facet Chaowattanapanit, Suteeraporn
Wongjirattikarn, Rachot
Chaisuriya, Nipon
Ungarreevittaya, Piti
Poosekeaw, Pirawan
Winaikosol, Kengkart
Choonhakarn, Charoen
Julanon, Narachai
Salao, Kanin
author_sort Chaowattanapanit, Suteeraporn
collection PubMed
description BACKGROUND: Prurigo nodularis (PN) is a chronic pruritic skin disease which can greatly impact patients’ quality of life. Moreover, the pathogenesis remains unclear, making it a difficult-to-treat condition. AIMS: To investigate the expression of interleukin-31 (IL-31) in serum and skin biopsy specimens of PN patients and healthy subjects and identify its possible correlation to disease severity and itch intensity. METHODS: Patients with PN and healthy volunteers were recruited for the study. Expression levels of IL-31 were measured by enzyme-linked immunosorbent assay and immunohistochemistry. Baseline characteristics, disease activity, itch intensity, and related laboratory results were collected. RESULTS: Forty-three PN patients and 31 healthy subjects participated in our study. The PN patients had significantly higher mean serum IL-31 levels than the healthy subjects (52.9 ± 18.2 versus 36.3 ± 10.7 pg/ml, p < 0.001). Epidermal and dermal PN lesions also exhibited significantly higher IL-31 expression compared with the healthy skin (p < 0.001 and p = 0.01, respectively). However, there was no significant difference in serum or lesional expression of IL-31 by disease severity or itch intensity. CONCLUSION: Increased IL-31 expression in serum and PN lesions suggests that IL-31 has a potential role in the pathogenesis of PN.
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spelling pubmed-93010992022-07-22 Increased IL-31 expression in serum and tissue protein in prurigo nodularis Chaowattanapanit, Suteeraporn Wongjirattikarn, Rachot Chaisuriya, Nipon Ungarreevittaya, Piti Poosekeaw, Pirawan Winaikosol, Kengkart Choonhakarn, Charoen Julanon, Narachai Salao, Kanin Ther Adv Chronic Dis Original Article BACKGROUND: Prurigo nodularis (PN) is a chronic pruritic skin disease which can greatly impact patients’ quality of life. Moreover, the pathogenesis remains unclear, making it a difficult-to-treat condition. AIMS: To investigate the expression of interleukin-31 (IL-31) in serum and skin biopsy specimens of PN patients and healthy subjects and identify its possible correlation to disease severity and itch intensity. METHODS: Patients with PN and healthy volunteers were recruited for the study. Expression levels of IL-31 were measured by enzyme-linked immunosorbent assay and immunohistochemistry. Baseline characteristics, disease activity, itch intensity, and related laboratory results were collected. RESULTS: Forty-three PN patients and 31 healthy subjects participated in our study. The PN patients had significantly higher mean serum IL-31 levels than the healthy subjects (52.9 ± 18.2 versus 36.3 ± 10.7 pg/ml, p < 0.001). Epidermal and dermal PN lesions also exhibited significantly higher IL-31 expression compared with the healthy skin (p < 0.001 and p = 0.01, respectively). However, there was no significant difference in serum or lesional expression of IL-31 by disease severity or itch intensity. CONCLUSION: Increased IL-31 expression in serum and PN lesions suggests that IL-31 has a potential role in the pathogenesis of PN. SAGE Publications 2022-07-19 /pmc/articles/PMC9301099/ /pubmed/35875833 http://dx.doi.org/10.1177/20406223221112561 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Chaowattanapanit, Suteeraporn
Wongjirattikarn, Rachot
Chaisuriya, Nipon
Ungarreevittaya, Piti
Poosekeaw, Pirawan
Winaikosol, Kengkart
Choonhakarn, Charoen
Julanon, Narachai
Salao, Kanin
Increased IL-31 expression in serum and tissue protein in prurigo nodularis
title Increased IL-31 expression in serum and tissue protein in prurigo nodularis
title_full Increased IL-31 expression in serum and tissue protein in prurigo nodularis
title_fullStr Increased IL-31 expression in serum and tissue protein in prurigo nodularis
title_full_unstemmed Increased IL-31 expression in serum and tissue protein in prurigo nodularis
title_short Increased IL-31 expression in serum and tissue protein in prurigo nodularis
title_sort increased il-31 expression in serum and tissue protein in prurigo nodularis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301099/
https://www.ncbi.nlm.nih.gov/pubmed/35875833
http://dx.doi.org/10.1177/20406223221112561
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