Cargando…

Penpulimab for Relapsed or Refractory Classical Hodgkin Lymphoma: A Multicenter, Single-Arm, Pivotal Phase I/II Trial (AK105-201)

BACKGROUND: Nearly all anti-PD-1 antibodies are of the IgG4 isotype, and thus possess residual FcR effector functions. Such anti-PD-1 antibodies are also associated with immune tolerance and escape due to instability of the CH3 domain and Fc-Fc interaction. In this trial, we examined the efficacy an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Yuqin, Zhou, Keshu, Jin, Chuan, Qian, Zhengzi, Hou, Ming, Fan, Lei, Li, Fei, Ding, Kaiyang, Zhou, Hui, Li, Xiaoling, Chen, Bing, Sun, Xiuhua, Song, Xianmin, Jiang, Ming, Zhang, Qingyuan, Liu, Lihong, Yu, Guohua, Hu, Yu, Zhao, Zheng, Liu, Ligen, Xue, Hongwei, Luo, Jun, He, Bai, Jin, Xiaoping, Zhao, Min, Li, Baiyong, Xia, Yu, Zhu, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301139/ https://www.ncbi.nlm.nih.gov/pubmed/35875118 http://dx.doi.org/10.3389/fonc.2022.925236

Ejemplares similares

Clinical Activity and Safety of Penpulimab (Anti-PD-1) With Anlotinib as First-Line Therapy for Unresectable Hepatocellular Carcinoma: An Open-Label, Multicenter, Phase Ib/II Trial (AK105-203)
por: Han, Chun, et al.
Publicado: (2021)

Penpulimab, an Fc-Engineered IgG1 Anti-PD-1 Antibody, With Improved Efficacy and Low Incidence of Immune-Related Adverse Events
por: Huang, Zhaoliang, et al.
Publicado: (2022)

A case report and literature review of immune checkpoint inhibitor-associated pneumonia caused by penpulimab
por: Gao, Rongmao, et al.
Publicado: (2023)

Penpulimab-induced complete atrioventricular block in a patient with metastatic renal cancer
por: Shen, Lishui, et al.
Publicado: (2023)

AK112, a novel PD-1/VEGF bispecific antibody, in combination with chemotherapy in patients with advanced non-small cell lung cancer (NSCLC): an open-label, multicenter, phase II trial
por: Zhao, Yuanyuan, et al.
Publicado: (2023)

LncRNA AK054921 and AK128652 are potential serum biomarkers and predictors of patient survival with alcoholic cirrhosis
por: Yang, Zhihong, et al.
Publicado: (2017)

Population pharmacokinetic/pharmacodynamic analysis of AK111, an IL-17A monoclonal antibody, in subjects with moderate-to-severe plaque psoriasis
por: Li, Qian, et al.
Publicado: (2022)

Case report: the dissociated response and clinical benefit of primary leiomyosarcoma of the bone treated with penpulimab plus lenvatinib after failed multi-line therapy
por: Wang, Bin, et al.
Publicado: (2023)

ak 47 /
por: Aguilar Martínez, Luis
Publicado: (2017)

P1145: PRELIMINARY RESULTS OF PENPULIMAB COMBINED WITH RMA(RITUXIMAB, METHOTREXATE, AND CYTARABINE) FOR NEWLY DIAGNOSED PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA (PCNSL)
por: Shen, Haorui, et al.
Publicado: (2023)

Efficacy, Safety and Pharmacokinetics of IL-17 Monoclonal Antibody Injection (AK111) in Patients with Moderate-to-Severe Plaque Psoriasis: A Randomized, Double-Blinded, Placebo-Controlled Phase Ib Multidose Escalation Clinical Study
por: Jiang, Congjun, et al.
Publicado: (2022)

Comparative analysis of buds transcriptome and identification of two florigen gene AkFTs in Amorphophallus konjac
por: Gao, Han, et al.
Publicado: (2022)

Successful Treatment of a Patient With Multiple-Line Relapsed Extensive-Stage Small-Cell Lung Cancer Receiving Penpulimab Combined With Anlotinib: A Case Report
por: Zhang, Zibo, et al.
Publicado: (2022)

Down-Regulation of lncRNA-AK001085 and its Influences on the Diagnosis of Ankylosing Spondylitis
por: Li, Xiang, et al.
Publicado: (2017)

Identification of the lncRNA, AK156230, as a novel regulator of cellular senescence in mouse embryonic fibroblasts
por: Chen, Yu-ning, et al.
Publicado: (2016)

Draft Genome Sequence of Listeria monocytogenes LM201, Isolated from Foodstuff
por: Wu, Yongpeng, et al.
Publicado: (2015)

Corrigendum: Successful treatment of a patient with multiple-line relapsed extensive-stage small-cell lung cancer receiving penpulimab combined with anlotinib: A case report
por: Zhang, Zibo, et al.
Publicado: (2022)

Non-stability of AK-invariant
por: Bandman, T, et al.
Publicado: (2003)

Human Enterovirus C105, China, 2017
por: Li, Maozhong, et al.
Publicado: (2019)

Memorandum 201
por: CERN. Geneva. Proton Synchrotron and Synchrocyclotron Committee
Publicado: (1984)

Response to trametinib in a nonsmall cell lung cancer patient with osimertinib resistance harboring GNAS R201C and R201H mutations: a case report
por: Lv, You, et al.
Publicado: (2022)

Silencing the HaAK Gene by Transgenic Plant-Mediated RNAi Impairs Larval Growth of Helicoverpa armigera
por: Liu, Feng, et al.
Publicado: (2015)

PB2144: PEARL: A STUDY TO ASSESS THE EFFICACY AND SAFETY OF PENPULIMAB PLUS LENALIDOMIDE, RITUXIMAB, GEMCITABINE AND OXALIPLATIN IN PATIENTS WITH RELAPSED/REFRACTORY DIFFUSE LARGE B CELL LYMPHOMA
por: Wei, X., et al.
Publicado: (2022)

PR‐DUB safeguards Polycomb repression through H2AK119ub1 restriction
por: Li, Rui, et al.
Publicado: (2023)

Adenylate kinase 2 (AK2) promotes cell proliferation in insect development
por: Chen, Ru-Ping, et al.
Publicado: (2012)

AK2 is an AMP-sensing negative regulator of BRAF in tumorigenesis
por: Kim, Hyunjoo, et al.
Publicado: (2022)

GSTP1 Ile105Val Polymorphism and Prostate Cancer Risk: Evidence from a Meta-Analysis
por: Wei, Bingbing, et al.
Publicado: (2013)

AK098656: a new biomarker of coronary stenosis severity in hypertensive and coronary heart disease patients
por: Wang, Xin, et al.
Publicado: (2022)

Proposed activities for A.K. Mitra
por: Germain, C
Publicado: (1977)

P1099: A PHASE II, MULTICENTER, SINGLE-ARM STUDY OF PARSACLISIB, A PI3KΔ INHIBITOR, IN RELAPSED OR REFRACTORY FOLLICULAR LYMPHOMA IN CHINA: UPDATED RESULTS FROM THE STUDY
por: Zheng, Zhong, et al.
Publicado: (2023)

Targeted Antiangiogenesis Gene Therapy Using Targeted Cationic Microbubbles Conjugated with CD105 Antibody Compared with Untargeted Cationic and Neutral Microbubbles
por: Zhou, Yu, et al.
Publicado: (2015)

Biochemical and Functional Studies of Lymphoid-Specific Tyrosine Phosphatase (Lyp) Variants S201F and R266W
por: Liu, Jing, et al.
Publicado: (2012)

LncRNA-AK149641 regulates the secretion of tumor necrosis factor-α in P815 mast cells by targeting the nuclear factor-kappa B signaling pathway
por: Zhou, Yao, et al.
Publicado: (2020)

Deficiency in AK9 causes asthenozoospermia and male infertility by destabilising sperm nucleotide homeostasis
por: Sha, Yanwei, et al.
Publicado: (2023)

Safety, Pharmacokinetics and Preliminary Efficacy of IL4-Rα Monoclonal Antibody AK120 in Both Healthy and Atopic Dermatitis Subjects: A Phase I, Randomized, Two-Part, Double-Blind, Placebo-Controlled, Dose-Escalation, First-In-Human Clinical Study
por: Wynne, Christopher John, et al.
Publicado: (2023)

The association of ODF4 with AK1 and AK2 in mice is essential for fertility through its contribution to flagellar shape
por: Ito, Chizuru, et al.
Publicado: (2023)

PB2272: PI3KΔ INHIBITOR LINPERLISIB FOR PATIENTS WITH RELAPSED OR REFRACTORY FOLLICULAR LYMPHOMA: SUBGROUP ANALYSIS OF A PHASE 2 TRIAL
por: Qiu, Lihua, et al.
Publicado: (2023)

PB2269: PI3KΔ INHIBITOR LINPERLISIB FOR ELDERLY PATIENTS WITH RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA: SUBGROUP ANALYSIS OF A PHASE 2 TRIAL
por: Sun, Xiuhua, et al.
Publicado: (2023)

Hypoxia-Inducible lncRNA-AK058003 Promotes Gastric Cancer Metastasis by Targeting γ-Synuclein()()
por: Wang, Yafang, et al.
Publicado: (2014)

AKS construction, bihamiltonian manifolds and Sato equations
por: Guha, P
Publicado: (1995)

Cannot write session to /tmp/vufind_sessions/sess_lgkkba6svi8blteavgt1bje0l9