Chalcone Derivatives From Abelmoschus manihot Seeds Restrain NLRP3 Inflammasome Assembly by Inhibiting ASC Oligomerization

Three chalcone derivatives, abelmanihotols A−C (1–3), and nine known compounds were isolated from A. manihot seeds, and their structures were determined using HRESIMS and NMR spectroscopic analysis. Compound 1 exhibited the most potent inhibitory effect (IC(50) = 4.79 ± 0.72 μM) against lipopolysacc...

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Detalles Bibliográficos
Autores principales: Su, Jinsong, Yang, Fujing, Kang, Xuemei, Liu, Jia, Tao, Yiwen, Diao, Qingchun, Meng, Xianli, Liu, Deming, Zhang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301202/
https://www.ncbi.nlm.nih.gov/pubmed/35873581
http://dx.doi.org/10.3389/fphar.2022.932198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301202/
https://www.ncbi.nlm.nih.gov/pubmed/35873581
http://dx.doi.org/10.3389/fphar.2022.932198

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