Cargando…

Dietary Acid Load (DAL), Glycated Hemoglobin A1c (HbA1c), and Metabolic Syndrome (MeS) Mediate the Association of the Adherence to the Dietary Approaches to Stopping Hypertension (DASH) and Mediterranean Diet (MeD) With Nonalcoholic Fatty Liver Disease

The study aimed to investigate the association of adults adhering to Dietary Approaches to Stop Hypertension (DASH) and Mediterranean diet (MeD) with nonalcoholic fatty liver disease (NAFLD) using structural equation modeling (SEM) in Iran. In this population-based cross-sectional study, 3,220 adult...

Descripción completa

Detalles Bibliográficos
Autores principales: Doustmohammadian, Azam, Nouri Saeidlou, Sakineh, Esfandyari, Saeed, Gholizadeh, Esmaeel, Maadi, Mansooreh, Motamed, Nima, Ajdarkosh, Hossein, Khoonsari, Mahmoodreza, Clark, Cain C. T., Zamani, Farhad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301207/
https://www.ncbi.nlm.nih.gov/pubmed/35873411
http://dx.doi.org/10.3389/fnut.2022.921415
_version_ 1784751376816930816
author Doustmohammadian, Azam
Nouri Saeidlou, Sakineh
Esfandyari, Saeed
Gholizadeh, Esmaeel
Maadi, Mansooreh
Motamed, Nima
Ajdarkosh, Hossein
Khoonsari, Mahmoodreza
Clark, Cain C. T.
Zamani, Farhad
author_facet Doustmohammadian, Azam
Nouri Saeidlou, Sakineh
Esfandyari, Saeed
Gholizadeh, Esmaeel
Maadi, Mansooreh
Motamed, Nima
Ajdarkosh, Hossein
Khoonsari, Mahmoodreza
Clark, Cain C. T.
Zamani, Farhad
author_sort Doustmohammadian, Azam
collection PubMed
description The study aimed to investigate the association of adults adhering to Dietary Approaches to Stop Hypertension (DASH) and Mediterranean diet (MeD) with nonalcoholic fatty liver disease (NAFLD) using structural equation modeling (SEM) in Iran. In this population-based cross-sectional study, 3,220 adults (44.65% female) aged ≥18 years were selected from the Amol Cohort Study (AmolCS). The dietary intakes were assessed by a validated 168-item semi-quantitative food-frequency questionnaire (FFQ). Residual method energy adjustment of MeD and DASH scores were calculated. Demographic characteristics and anthropometric and laboratory measurements were collected. NAFLD was diagnosed by an expert radiologist via ultrasound sonography. Based on the primary hypothesis, DASH, MeD, and NAFLD were fitted into models. Metabolic syndrome (MeS) as a potential risk factor directly affected NAFLD risk in all these models. In both genders, the higher adherence to DASH negatively affected NAFLD risk indirectly through the two following paths. (1) Dietary acid load (DAL) and metabolic syndrome (2) DAL and hemoglobin A1c (HbA1c). In addition, the higher DAL positively affected NAFLD risk among male participants indirectly via increasing HbA1c level and MeS (from DAL to HbA1c: β = 0.07, P < 0.001; from HbA1c to MeS: β = 0.10, P < 0.001). Similarly, in both genders, the relationship between MeD and NAFLD was mediated through (1) DAL, HbA1c, and MeS and (2) DAL and MeS. Further, among male participants, the MeD and NAFLD risk were also associated via the mediators of HbA1c and MeS. In female participants, the higher MeD score was directly associated with a reduction of NAFLD risk (β = −0.07, P = 0.008). The present study found three important mediators, including DAL, HbA1c, and MeS, in the association of DASH and MeD scores with NAFLD risk. Preventive and therapeutic interventions should target the mediators, including DAL, HbA1c, MeS, and its components, to reduce NAFLD incidence in the general population.
format Online
Article
Text
id pubmed-9301207
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-93012072022-07-22 Dietary Acid Load (DAL), Glycated Hemoglobin A1c (HbA1c), and Metabolic Syndrome (MeS) Mediate the Association of the Adherence to the Dietary Approaches to Stopping Hypertension (DASH) and Mediterranean Diet (MeD) With Nonalcoholic Fatty Liver Disease Doustmohammadian, Azam Nouri Saeidlou, Sakineh Esfandyari, Saeed Gholizadeh, Esmaeel Maadi, Mansooreh Motamed, Nima Ajdarkosh, Hossein Khoonsari, Mahmoodreza Clark, Cain C. T. Zamani, Farhad Front Nutr Nutrition The study aimed to investigate the association of adults adhering to Dietary Approaches to Stop Hypertension (DASH) and Mediterranean diet (MeD) with nonalcoholic fatty liver disease (NAFLD) using structural equation modeling (SEM) in Iran. In this population-based cross-sectional study, 3,220 adults (44.65% female) aged ≥18 years were selected from the Amol Cohort Study (AmolCS). The dietary intakes were assessed by a validated 168-item semi-quantitative food-frequency questionnaire (FFQ). Residual method energy adjustment of MeD and DASH scores were calculated. Demographic characteristics and anthropometric and laboratory measurements were collected. NAFLD was diagnosed by an expert radiologist via ultrasound sonography. Based on the primary hypothesis, DASH, MeD, and NAFLD were fitted into models. Metabolic syndrome (MeS) as a potential risk factor directly affected NAFLD risk in all these models. In both genders, the higher adherence to DASH negatively affected NAFLD risk indirectly through the two following paths. (1) Dietary acid load (DAL) and metabolic syndrome (2) DAL and hemoglobin A1c (HbA1c). In addition, the higher DAL positively affected NAFLD risk among male participants indirectly via increasing HbA1c level and MeS (from DAL to HbA1c: β = 0.07, P < 0.001; from HbA1c to MeS: β = 0.10, P < 0.001). Similarly, in both genders, the relationship between MeD and NAFLD was mediated through (1) DAL, HbA1c, and MeS and (2) DAL and MeS. Further, among male participants, the MeD and NAFLD risk were also associated via the mediators of HbA1c and MeS. In female participants, the higher MeD score was directly associated with a reduction of NAFLD risk (β = −0.07, P = 0.008). The present study found three important mediators, including DAL, HbA1c, and MeS, in the association of DASH and MeD scores with NAFLD risk. Preventive and therapeutic interventions should target the mediators, including DAL, HbA1c, MeS, and its components, to reduce NAFLD incidence in the general population. Frontiers Media S.A. 2022-07-07 /pmc/articles/PMC9301207/ /pubmed/35873411 http://dx.doi.org/10.3389/fnut.2022.921415 Text en Copyright © 2022 Doustmohammadian, Nouri Saeidlou, Esfandyari, Gholizadeh, Maadi, Motamed, Ajdarkosh, Khoonsari, Clark and Zamani. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Doustmohammadian, Azam
Nouri Saeidlou, Sakineh
Esfandyari, Saeed
Gholizadeh, Esmaeel
Maadi, Mansooreh
Motamed, Nima
Ajdarkosh, Hossein
Khoonsari, Mahmoodreza
Clark, Cain C. T.
Zamani, Farhad
Dietary Acid Load (DAL), Glycated Hemoglobin A1c (HbA1c), and Metabolic Syndrome (MeS) Mediate the Association of the Adherence to the Dietary Approaches to Stopping Hypertension (DASH) and Mediterranean Diet (MeD) With Nonalcoholic Fatty Liver Disease
title Dietary Acid Load (DAL), Glycated Hemoglobin A1c (HbA1c), and Metabolic Syndrome (MeS) Mediate the Association of the Adherence to the Dietary Approaches to Stopping Hypertension (DASH) and Mediterranean Diet (MeD) With Nonalcoholic Fatty Liver Disease
title_full Dietary Acid Load (DAL), Glycated Hemoglobin A1c (HbA1c), and Metabolic Syndrome (MeS) Mediate the Association of the Adherence to the Dietary Approaches to Stopping Hypertension (DASH) and Mediterranean Diet (MeD) With Nonalcoholic Fatty Liver Disease
title_fullStr Dietary Acid Load (DAL), Glycated Hemoglobin A1c (HbA1c), and Metabolic Syndrome (MeS) Mediate the Association of the Adherence to the Dietary Approaches to Stopping Hypertension (DASH) and Mediterranean Diet (MeD) With Nonalcoholic Fatty Liver Disease
title_full_unstemmed Dietary Acid Load (DAL), Glycated Hemoglobin A1c (HbA1c), and Metabolic Syndrome (MeS) Mediate the Association of the Adherence to the Dietary Approaches to Stopping Hypertension (DASH) and Mediterranean Diet (MeD) With Nonalcoholic Fatty Liver Disease
title_short Dietary Acid Load (DAL), Glycated Hemoglobin A1c (HbA1c), and Metabolic Syndrome (MeS) Mediate the Association of the Adherence to the Dietary Approaches to Stopping Hypertension (DASH) and Mediterranean Diet (MeD) With Nonalcoholic Fatty Liver Disease
title_sort dietary acid load (dal), glycated hemoglobin a1c (hba1c), and metabolic syndrome (mes) mediate the association of the adherence to the dietary approaches to stopping hypertension (dash) and mediterranean diet (med) with nonalcoholic fatty liver disease
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301207/
https://www.ncbi.nlm.nih.gov/pubmed/35873411
http://dx.doi.org/10.3389/fnut.2022.921415
work_keys_str_mv AT doustmohammadianazam dietaryacidloaddalglycatedhemoglobina1chba1candmetabolicsyndromemesmediatetheassociationoftheadherencetothedietaryapproachestostoppinghypertensiondashandmediterraneandietmedwithnonalcoholicfattyliverdisease
AT nourisaeidlousakineh dietaryacidloaddalglycatedhemoglobina1chba1candmetabolicsyndromemesmediatetheassociationoftheadherencetothedietaryapproachestostoppinghypertensiondashandmediterraneandietmedwithnonalcoholicfattyliverdisease
AT esfandyarisaeed dietaryacidloaddalglycatedhemoglobina1chba1candmetabolicsyndromemesmediatetheassociationoftheadherencetothedietaryapproachestostoppinghypertensiondashandmediterraneandietmedwithnonalcoholicfattyliverdisease
AT gholizadehesmaeel dietaryacidloaddalglycatedhemoglobina1chba1candmetabolicsyndromemesmediatetheassociationoftheadherencetothedietaryapproachestostoppinghypertensiondashandmediterraneandietmedwithnonalcoholicfattyliverdisease
AT maadimansooreh dietaryacidloaddalglycatedhemoglobina1chba1candmetabolicsyndromemesmediatetheassociationoftheadherencetothedietaryapproachestostoppinghypertensiondashandmediterraneandietmedwithnonalcoholicfattyliverdisease
AT motamednima dietaryacidloaddalglycatedhemoglobina1chba1candmetabolicsyndromemesmediatetheassociationoftheadherencetothedietaryapproachestostoppinghypertensiondashandmediterraneandietmedwithnonalcoholicfattyliverdisease
AT ajdarkoshhossein dietaryacidloaddalglycatedhemoglobina1chba1candmetabolicsyndromemesmediatetheassociationoftheadherencetothedietaryapproachestostoppinghypertensiondashandmediterraneandietmedwithnonalcoholicfattyliverdisease
AT khoonsarimahmoodreza dietaryacidloaddalglycatedhemoglobina1chba1candmetabolicsyndromemesmediatetheassociationoftheadherencetothedietaryapproachestostoppinghypertensiondashandmediterraneandietmedwithnonalcoholicfattyliverdisease
AT clarkcainct dietaryacidloaddalglycatedhemoglobina1chba1candmetabolicsyndromemesmediatetheassociationoftheadherencetothedietaryapproachestostoppinghypertensiondashandmediterraneandietmedwithnonalcoholicfattyliverdisease
AT zamanifarhad dietaryacidloaddalglycatedhemoglobina1chba1candmetabolicsyndromemesmediatetheassociationoftheadherencetothedietaryapproachestostoppinghypertensiondashandmediterraneandietmedwithnonalcoholicfattyliverdisease