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Increased Expression of Multiple Co-Inhibitory Molecules on Malaria-Induced CD8(+) T Cells Are Associated With Increased Function Instead of Exhaustion
Activated cytotoxic CD8(+) T cells can selectively kill target cells in an antigen-specific manner. However, their prolonged activation often has detrimental effects on tissue homeostasis and function. Indeed, overwhelming cytotoxic activity of CD8(+) T cells can drive immunopathology, and therefore...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301332/ https://www.ncbi.nlm.nih.gov/pubmed/35874786 http://dx.doi.org/10.3389/fimmu.2022.878320 |